Cytoskeletal genes regulating brain size
Cytoskeletal genes regulating brain size
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DOI：
10.1016/j.ceb.2005.11.004
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发表时间：
2006-02-01
影响因子：
7.5
通讯作者：
Woods, CG
中科院分区：
文献类型：
--
作者：
Bond, J;Woods, CG
人类进化中最显着的趋势之一是类人猿分支中大脑尺寸的急剧增加，并在人类中达到顶峰。特别令人感兴趣的是广阔的大脑皮层，据信它导致了我们执行更高认知功能的能力。最近对人类先天性小头畸形的研究发现了一些非冗余且特异性影响哺乳动物大脑大小的基因。这些基因似乎通过中心体的微管组织影响神经祖细胞的数量。
One of the most notable trends in human evolution is the dramatic increase in brain size that has occurred in the great ape clade, culminating in humans. Of particular interest is the vast expanse of the cerebral cortex, which is believed to have resulted in our ability to perform higher cognitive functions. Recent investigations of congenital microcephaly in humans have resulted in the identification of several genes that non-redundantly and specifically influence mammalian brain size. These genes appear to affect neural progenitor cell number through microtubular organisation at the centrosome.