Small pulmonary nodules: Evaluation with repeat CT - Preliminary experience
Small pulmonary nodules: Evaluation with repeat CT - Preliminary experience
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DOI：
10.1148/radiology.212.2.r99au33561
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发表时间：
1999-08-01
期刊：
影响因子：
19.7
通讯作者：
Henschke, CI
中科院分区：
文献类型：
--
作者：
Yankelevitz, DF;Gupta, R;Henschke, CI
目的：评估孤立性肺结节早期重复计算机断层扫描（CT）确定结节生长情况的应用。材料和方法：作者对结节幻影进行重复CT检查以评估其测量技术的准确性。然后，他们使用该技术评估了15名患者（9名男性，6名女性，年龄范围60-79岁，平均年龄66岁）的结节生长情况（9名恶性，6名良性），这些患者接受了重复CT检查，作为常规临床方案的一部分。最终诊断是通过手术切除或在不确定的活检后随访2年以上确定的。结果：假体实验结果表明，如果在结节的整个周长周围增加一个像素，所采用的面积变化测定方法足够灵敏，可以帮助检测结节的生长，使用标准指数生长曲线和已知的肿瘤生长速度，可以在30天内检测到体内的恶性生长。所有15例体内结节均通过早期重复CT正确分类。结论：早期重复CT的初步经验表明，第一次扫描后30天的单次CT扫描可以显示大多数恶性肿瘤的生长，小至5mm。
PUROSE: To assess the use of early repeat computed tomography (CT) of solitary pulmonary nodules to determine nodule growth.MATERIALS AND METHODS: The authors performed repeat CT of nodule phantoms to assess the accuracy of their measurement technique. They then used this technique to assess nodule growth (nine malignant, six benign) in 15 patients (nine men, six women; age range 60-79 years; average age, 66 years) who underrwent repeat CT as part of their routine clinical protocol. The final diagnosis was established with surgical resection or follow-up for more than 2 years after an indeterminate biopsy.RESULTS: Results of phantom experiments revealed that the method used to determine area change is sensitive enough to help detect nodule growth if one pixel is added around the entire circumference of a nodule, With use of standard exponential growth curves and known tumor growth rates, malignant growth could be detected in vivo within 30 days. All 15 in vivo nodules were correctly classified with early repeat CT.CONCLUSION: Preliminary experience with early repeat CT suggests that a single CT scan obtained 30 days after the first scan can depict growth in most malignant tumors as small as 5 mm.