Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring
Influence of maternal obesity on the multi-omics profiles of the maternal body, gestational tissue, and offspring
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DOI：
10.1016/j.biopha.2022.113103
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Zhengwei Yuan
中科院分区：
文献类型：
--
作者：
Duan Zhao;Yusi Liu;Shanshan Jia;Yiwen He;Xiaowei Wei;Dan Liu;Wei Ma;Wenting Luo;Hui Gu;Zhengwei Yuan
Epidemiological studies show that obesity during pregnancy affects more than half of the pregnancies in the developed countries and is associated with obstetric problems and poor outcomes. Obesity tends to increase the incidence of complications. Furthermore, the resulting offspring are also adversely affected. However, the molecular mechanisms of obesity leading to poor pregnancy outcomes remain unclear. Omics methods are used for genetic diagnosis and marker discovery. The aim of this review was to summarize the maternal and fetal pathophysiological alterations induced by gestational obesity,identified using multi-omics detection techniques, and to generalize the biological functions and potential mechanisms of the differentially expressed molecules.
