SPECIFICITY OF PROTECTION OF MAN IMMUNIZED AGAINST SPOROZOITE-INDUCED FALCIPARUM MALARIA
SPECIFICITY OF PROTECTION OF MAN IMMUNIZED AGAINST SPOROZOITE-INDUCED FALCIPARUM MALARIA
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DOI：
10.1097/00000441-197312000-00001
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发表时间：
1973-01-01
影响因子：
3.1
通讯作者：
HORNICK, RB
中科院分区：
文献类型：
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作者：
CLYDE, DF;MCCARTHY, VC;HORNICK, RB
这篇论文是发表在同一份杂志上的第一份报告的后续研究。已婚顾客。科学。， 1973, v. 266,169；通报，1974，第71期，摘要。[47]，关于经照射感染恶性疟原虫的史蒂芬按蚊叮咬对人体免疫的研究。其中一名志愿者在421天至1441次x射线照射期间受到了辐射。stephensii感染了缅甸（泰国）菌株p。恶性疟原虫在应对来自马来亚、巴拿马和菲律宾的恶性疟原虫同源毒株和其他毒株的挑战性感染时显示出高度的保护作用。由此产生的免疫是种特异性的，因为间日疟原虫Chesson菌株的攻击之后是明显的感染。受试者血清环孢子子沉淀（CSP）试验在1 / 40稀释条件下对所有相关菌株均呈阳性。但对切森氏疟原虫阴性。间日疟原虫。免疫后4个月，CSP试验在1 / 20稀释下仍呈阳性，目前正在调查保护性免疫的持续时间。j . Bruce-Chwatt。
This paper is a follow-up of the first report, published in the same journal[Am. J.Med. Sci., 1973, v. 266, 169; thisBulletin, 1974, v. 71, abstr. 447], on the immunization of human subjects by bites of irradiatedAnopheles stephensiinfected withPlasmodium falciparum. One of the volunteers who was exposed during the period of 421 days to 1441 X-irradiatedA. stephensiinfected with the Burma (Thai) strain ofP. falciparumshowed a high degree of protection in response to challenging infections with the homologous strain and other strains of falciparum malaria from Malaya, Panama and the Philippines. The resulting immunity was species-specific since a challenge with the Chesson strain of P.vivaxwas followed by an overt infection. The serum of the subject showed a positive circumsporozoite precipitation (CSP) test at 1 in 40 dilution against all the relevant strains ofP. falciparum, but was negative against the Chesson strain ofP. vivax. The CSP test remained positive at 1 in 20 dilution for 4 months after the immunization, and the duration of the protective immunity is now being investigated.L. J. Bruce-Chwatt.