WBN/Kob-Ht rats spontaneously develop dermatitis under conventional conditions:: Another possible model for atopic dermatitis
WBN/Kob-Ht rats spontaneously develop dermatitis under conventional conditions:: Another possible model for atopic dermatitis
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DOI：
10.1538/expanim.54.461
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发表时间：
2005-10-01
影响因子：
2.4
通讯作者：
Horikawa, T
中科院分区：
文献类型：
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作者：
Asakawa, M;Yoshioka, T;Horikawa, T
在常规饲养条件下饲养的WBN/KOB-Ht大鼠(Ht-大鼠)发生自发性皮炎。在本研究中，我们进行了组织病理学分析，以阐明Ht-大鼠皮炎的病理特征。然后，我们尝试检测从Ht-大鼠皮肤损伤中恢复的葡萄球菌种类。同时检测大鼠血清总IgE、IL-4和干扰素-γ水平。组织病理学检查显示皮损内有炎性细胞渗入。皮炎大鼠皮损处金黄色葡萄球菌恢复正常，血清总IgE和IL-4水平升高。这些结果表明，Ht-大鼠的皮炎与最近被提出作为人类特应性皮炎的动物模型的DS-NH小鼠相似。
WBN/Kob-Ht rats (Ht-rats) raised under conventional conditions spontaneously developed dermatitis. In this study, we carried out histopathological analysis to elucidate the pathological features of the dermatitis in Ht-rats. We then tried to detect Staphylococcus species recovered from the skin lesions of Ht-rats. We also measured the serum levels of total IgE, IL-4 and IFN-gamma in these rats. The histopathological data indicated that inflammatory cells had infiltrated the skin lesions. Staphylococcus aureus was recovered from the skin lesions, and the serum levels of total IgE and IL-4 were elevated in Ht-rats with dermatitis. These results suggest that dermatitis in Ht-rats is similar to that in the DS-Nh mice, which has recently been proposed as an animal model for human atopic dermatitis.