FAILURE OF ERYTHROMYCIN ESTOLATE THERAPY IN IN UTERO SYPHILIS.
FAILURE OF ERYTHROMYCIN ESTOLATE THERAPY IN IN UTERO SYPHILIS.
复制标题
埃斯托红霉素治疗子宫内梅毒失败。
DOI：
10.1001/jama.1964.03070140076020
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
J. Knox
中科院分区：
文献类型：
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作者：
M. South;D. Short;J. Knox
红霉素是已知青霉素过敏患者治疗梅毒最常用的抗生素。休斯顿社会卫生诊所已经进行了研究，提出了目前该药物在梅毒各个阶段的最佳剂量建议，但其在怀孕期间的使用尚未得到充分评估。本报告的主题是我们研究中一名患者的观察结果，该患者对 15 克红霉素埃斯托酯 (Ilosone) 治疗有良好的血清学反应，但所生婴儿死于先天性梅毒。病例报告 母亲，16 岁，妊娠 II，第 I，大约在怀孕第 6 个月时，出现生殖器周围、手掌和足底斑丘疹。临床诊断二期梅毒得到了性病研究实验室玻片试验（使用大西洋 VDRL 特异性抗原的絮凝试验）64 稀释度反应性的支持。由于
ERYTHROMYCIN is the most frequently administered antibiotic for the treatment of syphilis in patients with known penicillin allergy. Studies leading to current recommendations of optimum dosages of this drug in various stages of syphilis have been conducted in the Houston Social Hygiene Clinic, but its use during pregnancy has not yet been adequately evaluated. The observation of one patient in our study, who had a good serologic response to treatment with 15 gm of erythromycin estolate (Ilosone), but bore an infant who died of congenital syphilis, is the subject of this report. Report of a Case The mother, 16 years of age, gravida II, para I, in approximately the sixth month of pregnancy, had a perigenital, palmar, and plantar maculopapular rash. The clinical diagnosis, secondary syphilis, was supported by a Venereal Disease Research Laboratories slide test (flocculation test using the Atlantic VDRL's specific antigen) reactive at 64 dilutions. Because of