caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens
caRpools: an R package for exploratory data analysis and documentation of pooled CRISPR/Cas9 screens
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DOI：
10.1093/bioinformatics/btv617
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发表时间：
2016-02-15
期刊：
影响因子：
5.8
通讯作者：
Boutros, Michael
中科院分区：
文献类型：
--
作者：
Winter, Jan;Breinig, Marco;Boutros, Michael
通过CRISPR/Cas9介导的基因组工程进行遗传筛选已成为功能基因组学的有力工具。结果：CRISPR-AnalyzeR for pooled screens（caRpools）是一个用于探索性数据分析的R软件包，提供了一个完整的工作流程来分析CRISPR/Cas9筛选。为了进一步支持大规模筛查的分析，caRpools整合了筛查文档和标准化分析报告的生成。
Motivation: Genetic screens by CRISPR/Cas9-mediated genome engineering have become a powerful tool for functional genomics. However, there is currently a lack of end-to-end software pipelines to analyze CRISPR/Cas9 screens based on next generation sequencing.Results: The CRISPR-AnalyzeR for pooled screens (caRpools) is an R package for exploratory data analysis that provides a complete workflow to analyze CRISPR/Cas9 screens. To further support the analysis of large-scale screens, caRpools integrates screening documentation and generation of standardized analysis reports.