Self-Retained Amniotic Membrane Combined With Antiviral Therapy for Herpetic Epithelial Keratitis.
Self-Retained Amniotic Membrane Combined With Antiviral Therapy for Herpetic Epithelial Keratitis.
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DOI：
10.1097/ico.0000000000001316
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发表时间：
2017-11
期刊：
影响因子：
2.8
通讯作者：
Tseng SCG
中科院分区：
文献类型：
--
作者：
Cheng AMS;Tseng SCG
目的评价自体冷冻保存羊膜(CAM)联合口服抗病毒治疗疱疹上皮性角膜炎的疗效。对4例原发(1眼)和复发(3眼)单侧疱疹上皮性角膜炎患者的临床资料进行了回顾分析。比较治疗前后症状、结膜炎症、角膜染色和视力的变化。疱疹上皮性角膜炎表现为树枝状(3只眼)和地形性(1只眼)上皮样病变。在清创和放置PKS 5±3.7d后，所有患者的症状都有明显缓解，角膜上皮化迅速，眼表炎症减轻。视力由0.7±0.7提高到0.4±0.7logMAR(P=0.2)。随访2.7~50.8(20.3±21.7)个月，无症状。PKS联合口服阿昔洛韦便于早期干预，以加速疱疹上皮性角膜炎患者正常角膜上皮的恢复。
To evaluate the therapeutic benefit of self-retained cryopreserved amniotic membrane (CAM) in conjunction with oral antiviral therapy in herpetic epithelial keratitis. Retrospective review of 4 patients with primary (1 eye) and recurrent (3 eyes) unilateral herpetic epithelial keratitis treated with CAM through the placement of PROKERA® Slim (Bio-Tissue, Miami, FL) (PKS) in conjunction with oral acyclovir. Their symptoms, conjunctival inflammation, corneal staining, and visual acuity were compared before and after treatment. The herpetic epithelial keratitis presented as dendritic (3 eyes) and geographic (1 eye) epithelial lesions. Following epithelial debridement and placement of PKS for 5 ± 3.7 days, all patients reported a significant relief of symptoms, rapid corneal epithelization, and reduction of ocular surface inflammation. The visual acuity was also improved in all eyes from 0.7 ± 0.7 to 0.4 ± 0.7 logMAR (P = 0.2). They remained symptom-free during a follow-up period of 2.7 to 50.8 (20.3 ± 21.7) months. PKS in conjunction with oral acyclovir facilitates the ease of early intervention to accelerate restoration of a normal corneal epithelium in herpetic epithelial keratitis.