Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer
Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer
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DOI：
10.1007/s13277-010-0082-0
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发表时间：
2010-12-01
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影响因子：
--
通讯作者：
Wan, De-Sen
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文献类型：
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作者：
Fang, Yu-Jing;Lu, Zhen-Hai;Wan, De-Sen
雌激素受体β（ER β）是结肠癌患者中表达最高的蛋白质。基质金属蛋白酶7（MMP 7）在整个癌症进展过程中始终表达。我们先前已经表明，内分泌治疗可以抑制结肠癌细胞中MMP 7的表达。在这项研究中，我们的目的是确定ER β和MMP 7在结肠癌中的预后作用和相关性。通过免疫组织化学方法对423例I-III期结肠癌患者的正常粘膜和肿瘤组织中的ER β和MMP 7水平进行了评估。应用考克斯比例风险回归模型分析终生数据，包括总生存期（OS）和特定原因生存期（CSS）。ER β高表达组的5年生存率明显高于ER β低表达组（84.3%vs.63.9%，p < 0.05）。与MMP 7低表达的患者相比，MMP 7高表达与OS（分别为72%和90%，p = 0.008）和5年生存率（分别为86.6%和88.8%，p = 0.005）降低相关。在肿瘤细胞核ER β高表达的患者中，MMP 7的高表达与ER β高表达的结肠癌患者的OS和CSS相关。结论：ER β低表达是结肠癌的危险因素，MMP 7高表达是ER β阳性结肠癌患者的独立预后因素。
Estrogen receptor beta (ER beta) is the most highly expressed protein in patients with colon cancer. Matrix metalloproteinase 7 (MMP7) is consistently expressed throughout cancer progression. We have previously shown that endocrine therapy can inhibit MMP7 expression in colon cancer cells. In this study, we aim to identify the prognostic effects and correlation of ER beta and MMP7 in the context of colon cancer. ER beta and MMP7 levels were assessed by immunohistochemistry in normal mucosa and tumoral tissues from 423 patients with stage I-III colon cancer. The Cox proportional hazards regression model was applied to analyze the lifetime data, including overall survival (OS) and cause-specific survival (CSS). The 5-year survival rate was significantly higher in patients with high expression of nuclear ER beta than in patients with low expression (84.3% vs. 63.9%, respectively, p < 0.05). High expression of MMP7 was related to decreased OS (72% vs. 90%, respectively, p = 0.008) and 5-year survival (86.6% vs. 88.8%, respectively, p = 0.005) compared to patients with low expression of MMP7. In the subset of patients with high expression levels of tumoral nuclear ER beta, high expression of MMP7 was related to OS and CSS among colon cancer patients with high expression of ER beta. In conclusion, our results suggest that low expression of ER beta was a risk factor in colon cancer, and high expression of MMP7 was an independent prognostic factor of ER beta-positive patients with colon cancer.