The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.
The contested role of uracil DNA glycosylase in immunoglobulin gene diversification.
复制标题
尿嘧啶 DNA 糖基化酶在免疫球蛋白基因多样化中的有争议的作用。
DOI：
10.1016/j.tig.2005.02.013
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Storb,Ursula
中科院分区：
文献类型：
--
作者：
Longerich,Simonne;Storb,Ursula
Class switch recombination (CSR) and somatic hypermutation (SHM) of immunoglobulin (Ig) genes are initiated by the activation-induced cytosine deaminase AID. The resulting uracils in Ig genes were believed to be removed by the uracil glycosylase (UNG) and the resulting abasic sites treated in an error-prone fashion, creating breaks in the Ig switch regions and mutations in the variable regions. A recent report suggests that UNG does not act as a glycosylase in CSR and SHM but rather has unknown activity subsequent to DNA breaks that were created by other mechanisms.
