Architecture and microstructure of cortical bone in reconstructed canine mandibles after bone transport distraction osteogenesis.
Architecture and microstructure of cortical bone in reconstructed canine mandibles after bone transport distraction osteogenesis.
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DOI：
10.1007/s00223-011-9529-6
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发表时间：
2011-11
影响因子：
4.2
通讯作者：
Opperman, Lynne A.
中科院分区：
文献类型：
--
作者：
Zapata, Uriel;Halvachs, Emily K.;Dechow, Paul C.;Elsalanty, Mohammed E.;Opperman, Lynne A.
使用骨运输牵张成骨重建犬下颌骨已被证明是一种合适的方法，用于纠正由癌症，枪击和创伤引起的节段性骨缺损。虽然新的再生皮质骨的机械质量似乎与矿化过程有关，但关于新骨组织的微观结构模式的几个问题仍然没有答案。本研究的目的是量化再生和对照皮质骨之间可能存在的任何显微结构差异。对5只成年美国猎狐犬进行了单侧下颌骨转移牵张术，以修复30-35 mm的骨缺损。在巩固期开始后12周处死动物。从下颌骨重建面的舌板和颊板的上级、内侧和下侧提取14个圆柱形皮质样本，从下颌骨对侧采集21个样本。使用组织形态学和显微计算机断层扫描技术对标本进行评价，以比较其微观结构。除了哈佛氏管面积的差异外，组织形态计量学分析表明再生和对照皮质骨之间的显微结构没有统计学差异。形态学评价表明，一致的各向异性水平可能与牵引矢量。在12周的巩固后，在骨运输牵张成骨过程中产生的骨在微观结构、结构和机械性能方面与天然骨相当。据认为，经过足够的时间后，再生骨的性质将与天然骨的性质相同。
Reconstruction of the canine mandible using bone transport distraction osteogenesis has been shown to be a suitable method for correcting segmental bone defects produced by cancer, gunshots, and trauma. Although the mechanical quality of the new regenerate cortical bone seems to be related to the mineralization process, several questions regarding the micro-structural patterns of the new bony tissue remain unanswered. The purpose of this study was to quantify any microstructural differences that may exist between the regenerate and control cortical bone. Five adult American foxhound dogs underwent unilateral bone transport distraction of the mandible to repair 30–35 mm bone defects. Animals were sacrificed 12 weeks after the beginning of the consolidation period. Fourteen cylindrical cortical samples were extracted from the superior, medial, and inferior aspects of the lingual and buccal plates of the reconstructed aspect of the mandible and 21 specimens were collected similarly from the contralateral aspect of the mandible. The specimens were evaluated using histomorphometric and micro-computed tomography techniques to compare their microstructure. Except for differences in Haversian canal area, histomorphometric analyses suggested no statistical differences in microstructure between regenerate and control cortical bone. Morphological evaluation suggested a consistent level of anisotropy possibly related to the distraction vector. After 12 weeks consolidation, bone created during bone transport distraction osteogenesis is comparable to native bone in microstructure, architecture, and mechanical properties. It is proposed that after enough time, the properties of the regenerate bone will be identical to that of native bone.
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DOI：
10.1054/ijom.2003.0424
发表时间：
2003-10-01
影响因子：
2.4
作者：
Perrott, DH;Rahn, B;Kaban, LB
通讯作者：
Kaban, LB
DOI：
10.1016/j.cxom.2008.04.005
发表时间：
2008-09-01
影响因子：
--
作者：
Spagnoli, Daniel
通讯作者：
Spagnoli, Daniel
影响因子：
2.2
作者：
Rho, JY;Kuhn-Spearing, L;Zioupos, P
通讯作者：
Zioupos, P
影响因子：
3.6
作者：
SNYDER, CC;LEVINE, GA;BROWNE, EZ
通讯作者：
BROWNE, EZ
影响因子：
4.2
作者：
Currey, John
通讯作者：
Currey, John