Editorial for the MCE special issue on "FXR and metabolism".
Editorial for the MCE special issue on "FXR and metabolism".
复制标题
MCE 特刊“FXR 和新陈代谢”的社论。
DOI：
10.1016/j.mce.2023.111889
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发表时间：
2023
影响因子：
4.1
通讯作者：
Wooton-Kee,ClaviaRuth
中科院分区：
文献类型：
--
作者：
Kim,KangHo;Wooton-Kee,ClaviaRuth
这篇社论总结了不同的评论文章包含在分子和细胞内分泌学特刊。本期特刊重点介绍了FXR在调节营养和代谢稳态中的各种作用。FXR是一种转录因子，控制体内多个组织中控制胆固醇、胆汁酸、葡萄糖和脂质水平的基因表达。在几篇文章中讨论了针对FXR的治疗方法的效用。技术摘要：代谢稳态是一个紧密协调的过程，以平衡细胞的营养需求。来自亲脂前体的代谢产物是一组高度保守的转录因子的配体，称为核受体。核受体由可变n端区、高度保守的含DNA结合域锌指区、铰链区和配体结合域组成。第一个描述的核受体是类固醇激素核受体（雌激素受体，糖皮质激素受体），核受体领域已经扩展到代谢的各个领域，包括葡萄糖和脂质代谢，胆汁酸运输和合成的调节，以及免疫学。核受体farnesoid X受体FXR （NR1H4）在代谢协调中起中心作用，特别是在肝脏、肠道和脂肪组织中。《特刊：FXR与代谢》综述收录了有关FXR在代谢中的应用的论文。
This editorial summarizes the different review articles contained in the Special Issue of Molecular and Cellular Endocrinology. This Special Issue was focused on the various roles of FXR in regulation of nutrient and metabolic homeostasis. FXR is a transcription factor that controls the expression of genes that control cholesterol, bile acid, glucose, and lipid levels in multiple tissues in the body. The utility of therapeutics targeting FXR was discussed in several of the articles.Technical Abstract: Metabolic homeostasis is a tightly coordinated process to balance cellular nutrient requirements. The metabolic products derived from lipophilic precursors are ligands for a group of highly conserved transcription factors known as nuclear receptors. Nuclear receptors are comprised of a variable N-terminal region, a highly conserved zinc-finger containing DNA binding domain, a hinge region, and a ligand binding domain. The first nuclear receptors described were the steroid hormone nuclear receptors (estrogen receptor, glucocorticoid receptor), and the nuclear receptor field has expanded to encompass diverse areas of metabolism, including glucose and lipid metabolism, regulation of bile acid transport and synthesis, and immunology. The nuclear receptor farnesoid X receptor, FXR (NR1H4), has a central role in coordination of metabolism, particularly in the liver, intestine, and adipose tissue. The Special Issue: FXR and Metabolism review encompasses papers devoted to FXR in metabolism.