The clinical and immunological features of pediatric COVID-19 patients in China
The clinical and immunological features of pediatric COVID-19 patients in China
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DOI：
10.1016/j.gendis.2020.03.008
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发表时间：
2020-12-01
期刊：
影响因子：
6.8
通讯作者：
Huang, Ai-Long
中科院分区：
文献类型：
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作者：
Chen, Juan;Zhang, Zhen-Zhen;Huang, Ai-Long
2019年12月，由新型冠状病毒(SARS-CoV-2)引起的2019年冠状病毒病(新冠肺炎)在武汉、中国出现，并在全球迅速传播。儿科对新冠肺炎的临床特点和免疫学特点了解较少。分析12例确诊为新冠肺炎的儿科患者的临床特点和治疗结果。对儿童患者的免疫学特征进行了调查，并与20例成人患者进行了比较。中位年龄为14.5岁(0.64-17岁)，其中6名患者为男性。平均潜伏期为8d。临床上以咳嗽(9/12，75%)和发热(7/12，58.3%)为最常见症状。4例(33.3%)患者在发病过程中出现腹泻。免疫功能方面，儿童T细胞总数、CD8+T细胞和B细胞数量高于成人(P<；0.05)，而CRP水平低于成人(P<；0.05)。磨玻璃样阴影(GGO)和局部斑片状阴影是胸部CT的典型征象。所有患者均接受抗病毒及对症治疗，入院后3~4d症状缓解。儿科患者症状轻微，但潜伏期较长。感染SARS-CoV-2的儿童免疫功能不同，T细胞数量较高，炎症因子水平较低，可能与临床症状较轻有关。建议对有SARS-CoV-2接触史的儿童，不论临床症状如何，均应进行核酸检测或血清抗SARS-CoV-2的IgM/IgG抗体检测。版权所有(C)2020，重庆医科大学。爱思唯尔B.V.制作和主办。
In December 2019, the corona virus disease 2019 (COVID-19) caused by novel coronavirus (SARS-CoV-2) emerged in Wuhan, China and rapidly spread worldwide. Few information on clinical features and immunological profile of COVID-19 in paediatrics. The clinical features and treatment outcomes of twelve paediatric patients confirmed as COVID-19 were analyzed. The immunological features of children patients was investigated and compared with twenty adult patients. The median age was 14.5-years (range from 0.64 to 17), and six of the patients were male. The average incubation period was 8 days. Clinically, cough (9/ 12, 75%) and fever (7/12, 58.3%) were the most common symptoms. Four patients (33.3%) had diarrhea during the disease. As to the immune profile, children had higher amount of total T cell, CD8+ T cell and B cell but lower CRP levels than adults (P < 0.05). Ground-glass opacity (GGO) and local patchy shadowing were the typical radiological findings on chest CT scan. All patients received antiviral and symptomatic treatment and the symptom relieved in 3-4 days after admitted to hospital. The paediatric patients showed mild symptom but with longer incubation period. Children infected with SARS-CoV-2 had different immune profile with higher T cell amount and low inflammatory factors level, which might ascribed to the mild clinical symptom. We advise that nucleic acid test or examination of serum IgM/IgG antibodies against SARS-CoV-2 should be taken for children with exposure history regardless of clinical symptom. Copyright (C) 2020, Chongqing Medical University. Production and hosting by Elsevier B.V.