Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography - Comparison Between Drug-Eluting and Bare-Metal Stents
Qualitative and Quantitative Assessment of Stent Restenosis by Optical Coherence Tomography - Comparison Between Drug-Eluting and Bare-Metal Stents
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DOI：
10.1253/circj.cj-12-0610
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发表时间：
2013-03-01
影响因子：
3.3
通讯作者：
Hirata, Ken-ichi
中科院分区：
文献类型：
--
作者：
Nagoshi, Ryoji;Shinke, Toshiro;Hirata, Ken-ichi
背景：我们假设药物洗脱支架（DES）和裸金属支架（BMS）的支架内再狭窄（ISR）的组织成分可能不同，这些差异可以通过定性和定量光学相干断层扫描（OCT）分析来区分。方法与结果：采用OCT对122例初始ISR病变（西罗莫司洗脱支架：n=28；紫杉醇洗脱支架：n=51; BMS: n=43）进行评估。根据其OCT外观，将病变分为均匀型、分层型和非均匀型。量化了新内膜组织（NIT）的后向散射、衰减和信号强度的光学特性。为了评估球囊血管成形术（BA）后的血管反应，计算NIT面积的缩小率（NITA） （BA前- BA后的NITA / BA前最小管腔截面积的NITA）。在形态学OCT模式中，DES以层状型为主，而BMS则呈均匀型(P
Background: We hypothesized that the tissue components of in-stent restenosis (ISR) might differ between drug-eluting stents (DES) and bare-metal stents (BMS) and that these differences could be distinguished by qualitative and quantitative optical coherence tomography (OCT) analyses.Methods and Results: One-hundred and twenty-two initial ISR lesions (sirolimus-eluting stents: n=28; paclitaxel-eluting stents: n=51; BMS: n=43) were evaluated with OCT. Based on their OCT appearance, the lesions were classified as homogeneous, layered or heterogeneous. The optical properties of backscatter, attenuation and signal intensity of the neointimal tissue (NIT) were quantified. To evaluate the vascular response after balloon angioplasty (BA), the rate of reduction of the NIT area (NITA) was calculated (NITA before - after BA/NITA before BA at the minimum lumen cross-sectional area). Among the morphologic OCT patterns, the layered type was predominant with DES, whereas lesions were homogeneous with BMS (P