New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma.
New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma.
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DOI：
10.1007/s11926-007-0008-z
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发表时间：
2007-05-01
影响因子：
5
通讯作者：
Krieg, Thomas
中科院分区：
文献类型：
--
作者：
Abraham, David J;Eckes, Beate;Krieg, Thomas
在过去的二十年里，间充质成纤维细胞的概念已经从一种相对惰性的结构细胞类型演变为一种动态的、多潜能的细胞谱系，控制着正常结缔组织的形成、动态平衡和修复，并在病理性瘢痕形成和纤维化中发挥主要作用。在伤口愈合和组织修复中，成纤维细胞提供促炎信号，并合成间质胶原、纤维连接蛋白和其他基质成分来修复受损组织。成纤维细胞可以分化为肌成纤维细胞，这是一种特殊的收缩细胞类型，负责伤口闭合、组织收缩和疤痕形成。本文综述了目前我们对间充质细胞的起源及其在过度瘢痕和纤维化形成以及系统性纤维性疾病硬皮病中的作用的了解。
The concept of mesenchymal fibroblasts has evolved over the past two decades from a relatively inert structural cell type to a dynamic, pluripotent cell lineage controlling normal connective tissue formation, homeostasis, and repair and as principle players in pathogenic scarring and fibrosis. In wound healing and tissue repair, fibroblasts provide proinflammatory signals and synthesize interstitial collagens, fibronectins, and other matrix components to repair the damaged tissue. Fibroblasts can differentiate into the myofibroblast, a specialized contractile cell type responsible for wound closure, tissue contraction, and scarring. This article reviews our current understanding of the origins of mesenchymal cells and their role in excessive scarring and fibrogenesis and in the systemic fibrotic disease scleroderma.