Cellular control lies in the balance of forces
Cellular control lies in the balance of forces
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DOI：
10.1016/s0955-0674(98)80145-2
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发表时间：
1998-04-01
影响因子：
7.5
通讯作者：
Ingber, DE
中科院分区：
文献类型：
--
作者：
Chicurel, ME;Chen, CS;Ingber, DE
在活细胞的细胞骨架内产生的机械张力正在成为从染色体运动的控制到脊椎动物脑的形态发生的各种情况下的生物功能的关键调节器。在这篇文章中，我们回顾了最近在理解细胞如何产生，传输和感知机械张力以及它们如何使用这些力来控制它们的形状和行为方面取得的进展。结合力学、结构以及化学的细胞调节综合观点开始出现。(C)Current Biology Ltd ISSN 0955-0674。
Mechanical tension generated within the cytoskeleton of living cells is emerging as a critical regulator of biological function in diverse situations ranging from the control of chromosome movement to the morphogenesis of the vertebrate brain. In this article, we review recent advances that have been made in terms of understanding how cells generate, transmit and sense mechanical tension, as well as how they use these forces to control their shape and behavior. An integrated view of cell regulation that incorporates mechanics and structure as well as chemistry is beginning to emerge. (C) Current Biology Ltd ISSN 0955-0674.