Overrepresentation of Th1-and Th17-like Follicular Helper T Cells in Coronary Artery Disease
Overrepresentation of Th1-and Th17-like Follicular Helper T Cells in Coronary Artery Disease
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冠状动脉疾病中 Th1 和 Th17 样滤泡辅助 T 细胞的过度表达
DOI：
10.1007/s12265-015-9662-0
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发表时间：
2015-12-01
影响因子：
3.4
通讯作者：
Liang, Chun
中科院分区：
文献类型：
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作者：
Ding, Ru;Gao, Wenwu;Liang, Chun
T细胞和B细胞在冠状动脉疾病（CAD）的发病过程中起重要作用。在这里，我们研究了循环滤泡辅助性T（Tfh）细胞在CAD中的作用。与非CAD对照组相比，CAD患者循环Tfh水平升高。此外，CAD患者的循环Tfh表现出Th 1和Th 17样表型和异常细胞因子表达的频率增加。与B细胞的共培养实验表明，来自CAD患者的Tfh在诱导B细胞产生抗体、促进浆母细胞分化和抑制B10细胞分化方面更有效。更重要的是，我们发现循环Tfh向Th 1/Th 17样细胞的偏移与CAD患者的B细胞炎症和低密度脂蛋白水平直接相关。总之，我们的数据表明CAD患者血液Tfh组成的偏斜，这导致B细胞炎症的显著变化。
T cells and B cells play substantial roles in the process of coronary artery disease (CAD). Here, we examined the role of circulating follicular helper T (Tfh) cells in CAD. Compared to non-CAD controls, CAD patients had increased levels of circulating Tfh. Also, circulating Tfh in CAD patients exhibited increased frequencies of Th1- and Th17-like phenotypes and aberrant cytokine expressions. Coculture experiments with B cells showed that Tfh from CAD patients were more potent at inducing antibody production from B cells, enhancing plasmablast differentiation and suppressing B10 cell differentiation. Importantly, we found that the skewing of circulating Tfh toward the Th1/Th17-like cells was directly correlated with B cell inflammation and low density lipoprotein level in CAD patients. Together, our data demonstrated a skewing of blood Tfh composition in CAD patients, which resulted in significant changes in B cell inflammation.