The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease
The influence of the eradication of Helicobacter pylori on gastric ghrelin, appetite, and body mass index in patients with peptic ulcer disease
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DOI：
10.1111/j.1440-1746.2008.05415.x
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发表时间：
2008-12-01
影响因子：
4.1
通讯作者：
Baik, Hyun Wook
中科院分区：
文献类型：
--
作者：
Jang, Eun Jeong;Park, Sang Woon;Baik, Hyun Wook
幽门螺杆菌（H.幽门螺杆菌）感染影响胃瘦素和胃饥饿素分泌，其确切的致病作用尚未被证实。本研究旨在探讨H.幽门螺杆菌根除对消化性溃疡患者血浆或胃内ghrelin水平、体重指数（BMI）以及由此产生的食欲水平的影响。幽门相关的活动性十二指肠溃疡或胃溃疡用7周的抗分泌药物治疗，然后用7天的根除方案治疗。治疗前后检测血浆和组织Ghrelin水平、肿瘤坏死因子-α（TNF-α）mRNA、体重指数（BMI）和食欲量表。对10例同时接受溃疡治疗和H.溃疡愈合或幽门螺杆菌根除后胃ghrelin mRNA表达显著增加。幽门螺杆菌根除后胃TNF-α mRNA表达降低，而幽门螺杆菌根除后胃TNF-α mRNA表达降低。根除幽门与这些变化平行的是，在溃疡愈合和H。根除幽门BMI的增加与溃疡愈合和H.幽门螺杆菌根除治疗。在对10例进行额外内镜检查的患者进行的亚组分析中，溃疡治疗与血浆ghrelin水平升高和组织ghrelin表达相关，与H无关。随着胃溃疡愈合和幽门螺杆菌根除，胃饥饿素的组织水平恢复和食欲状态改善。根除幽门
Helicobacter pylori (H. pylori) infection has been known to influence the gastric leptin and ghrelin secretion, for which the exact pathogenic role has not been documented yet. This study was designed to investigate the influence of H. pylori eradication on plasma or gastric levels of ghrelin, body mass index (BMI), and resultant levels of appetite in patients with peptic ulcer disease.Twenty-two patients with H. pylori-associated active duodenal or gastric ulcer were treated with 7 weeks of antisecretory medication followed with 7 days of eradication regimen. The plasma and tissue ghrelin levels, tumor necrosis factor-alpha (TNF-alpha) mRNA, BMI, and appetite scale were checked before and after treatment. An additional endoscopic examination was conducted in 10 patients taking both ulcer treatment and H. pylori eradication.Gastric ghrelin mRNA expression was significantly increased after either ulcer healing or H. pylori eradication, whereas gastric TNF-alpha mRNA expression was decreased after ulcer treatment and H. pylori eradication. In parallel with these changes, the visual analog scales for hunger and prospective food consumption were significantly increased after ulcer healing and H. pylori eradication. An increase in BMI was not statistically related to ulcer healing and H. pylori eradication therapy. In the subgroup analysis of 10 patients performed with additional endoscopic examination, ulcer treatment was associated with increased plasma ghrelin level and tissue ghrelin expression irrelevant to H. pylori eradication.Restored tissue levels of ghrelin and improved status of appetite was achieved with gastric ulcer healing and H. pylori eradication.