Clinical assessment of the macula by retinal topography and thickness mapping.
Clinical assessment of the macula by retinal topography and thickness mapping.
复制标题
通过视网膜地形图和厚度测绘对黄斑进行临床评估。
DOI：
10.1016/s0002-9394(14)70903-1
复制
发表时间：
1997
影响因子：
4.2
通讯作者：
Shahidi,M
中科院分区：
文献类型：
--
作者：
Gieser,JP;Rusin,MM;Mori,M;Blair,NP;Shahidi,M
目的报告一种评估视网膜结构病理改变的定量和客观方法，以改善黄斑疾病的评估。方法我们使用基于扫描视网膜厚度分析仪的系统来生成视网膜的连续光学切片图像，并提供正常受试者和具有代表性黄斑病变（包括外伤性黄斑裂孔、中心性浆液性脉络膜视网膜病变、视网膜分支静脉阻塞、糖尿病性黄斑水肿和视网膜病变）患者的视网膜地形和厚度图。结果该系统在玻璃体视网膜和脉络膜视网膜界面成像方面的有效性在正常受试者和患有各种黄斑病的患者中得到证实。正常眼的视网膜地形和厚度的测绘与正常解剖结构良好相关，清楚地描绘出中央凹凹陷。糖尿病黄斑水肿患者的视网膜厚度图显示视网膜增厚且没有中心凹凹陷。患有中心性浆液性脉络膜视网膜病变和视网膜分支静脉阻塞的患者玻璃体视网膜表面升高。相反，视网膜色素上皮脱离的患者玻璃体视网膜界面相对平坦，但脉络膜视网膜表面不规则升高。结论视网膜地形和厚度的定量绘图是一种有前景的工具，可以改善黄斑疾病的评估。
PurposeTo report a quantitative and objective method for assessing pathologic alterations in retinal structures to improve the evaluation of macular diseases.MethodsWe used a system based on the scanning retinal thickness analyzer to generate serial optical section images of the retina and provide mapping of the retinal topography and thickness in a normal subject and in patients with representative maculopathies including traumatic macular hole, central serous chorioretinopathy, branch retinal vein occlusion, diabetic macular edema, and retinal pigment epithelial detachment.ResultsThe effectiveness of the system in imaging both the vitreoretinal and chorioretinal interfaces was confirmed in the normal subject and in patients with various maculopathies. Mapping of retinal topography and thickness in a normal eye correlated well with normal anatomy, delineating the foveal depression clearly. The retinal thickness map in a patient with diabetic macular edema showed thickening of the retina and absence of a foveal depression. The patients with central serous chorioretinopathy and branch retinal vein occlusion had an elevated vitreoretinal surface. Conversely, the patient with retinal pigment epithelial detachments had a relatively flat vitreoretinal interface but an irregularly elevated chorioretinal surface.ConclusionQuantitative mapping of retinal topography and thickness is a promising tool that may improve evaluation of macular diseases.