Curcumin- and cyclopamine-loaded liposomes to enhance therapeutic efficacy against hepatic fibrosis" has been accepted for publication in "Drug Design, Development and Therapy
Curcumin- and cyclopamine-loaded liposomes to enhance therapeutic efficacy against hepatic fibrosis" has been accepted for publication in "Drug Design, Development and Therapy
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DOI：
10.2147/dddt.s287442
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发表时间：
2020
影响因子：
4.8
通讯作者：
Xiaofan Fei
中科院分区：
文献类型：
--
作者：
Ting Zhang;Yanping Li;Yi Song;Xiaoshuang Chen;Jing Li;Qiang Peng;Jinhan He;Xiaofan Fei
Background and purpose：Hepatic fibrosis is a public health problem characterized by activation of hepatic stellate cells (HSCs), which triggers excessive production of extracellular matrix (ECM). Inhibition of HSC activation may be an effective treatment. Since various pathways control HSC activation, a combination of drugs with different mechanisms may be more effective than monotherapy. .Methods: Here we prepared liposomes loaded with curcumin and cyclopamine to inhibit HSC activation. We systematically analyzed the physicochemical characteristics of liposomes loaded with the two drugs, as well as their effects on HSC proliferation, activation and collagen production on gene, protein and cellular levels. .Results: The prepared liposomes helped solubilize both drugs, contributing to their uptake by cells. Liposomes loaded with both drugs inhibited cell proliferation, migration and invasion, as well as induced more apoptosis and perturbed the cell cycle more than the free combination of both drugs in solution or liposomes loaded with either drug alone. Liposomes loaded with both drugs strongly suppressed HSC activation and collagen secretion..Conclusion: Our results suggest that liposome encapsulation can increase the uptake of curcumin and cyclopamine as well as the synergism between them in anti-fibrosis. This approach shows potential for treating hepatic fibrosis.
