1H and 13C NMR signal assignments of Paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp (tree 1-7)
1H and 13C NMR signal assignments of Paecilin A and B, two new chromone derivatives from mangrove endophytic fungus Paecilomyces sp (tree 1-7)
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DOI：
10.1002/mrc.2035
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发表时间：
2007-09-01
影响因子：
2
通讯作者：
Lin, Yongcheng
中科院分区：
文献类型：
--
作者：
Guo, Zhiyong;She, Zhigang;Lin, Yongcheng
从红树林内生植物中分离出两种新的天然产物，命名为青青素 A (1) 和 B (2)，以及两种已知化合物癸二酸 D (3) 和 (11)-cytochalasa-6(12),13-diene-1,21-dione-16,18-二甲基-7-羟基-10-苯基-(7S*,13E,16S*,18S*) (4)。真菌，拟青霉属 sp。 （树1-7）来自南中国海。包括 COSY、HMQC 和 HMBC 在内的 1D 和 2D NMR 实验用于确定其结构。在我们的细胞毒性测定中，secalonic D (3) 对 KB 细胞具有细胞毒性，IC50 < 1 mu g ml(-1)，并且抑制人拓扑异构酶 I，IC50 为 0.16 mu mol ml(-1)。1、2 和 4 对 KB 细胞没有活性。版权所有 (C) 2007 John Wiley & Sons, Ltd.
Two new natural products, named paecilin A (1) and B (2), together with two known compounds secalonic acid D (3) and (11)-cytochalasa-6(12),13-diene-1,21-dione-16,18-dimethyl-7-hydroxy-10-phenyl-(7S*,13E,16S*,18S*) (4), were isolated from the mangrove endophytic fungus, Paecilomyces sp. (tree 1-7) from the South China Sea. 1D and 2D NMR experiments including COSY, HMQC, and HMBC were used for the determination of their structures. In our cytotoxicity assays, secalonic D (3) showed cytotoxicity toward KB cells with IC50 < 1 mu g ml(-1) and inhibiting human topoisomerase I with IC50 at 0.16 mu mol ml(-1).1, 2, and 4 showed no activity to KB cells. Copyright (C) 2007 John Wiley & Sons, Ltd.