Analysis of the clinicopathological features and prognostic factors in 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction
Analysis of the clinicopathological features and prognostic factors in 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction
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734例回汉族食管胃结合部腺癌临床病理特征及预后因素分析
DOI：
10.1016/j.suronc.2018.07.008
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发表时间：
2018-09-01
影响因子：
2.3
通讯作者：
Yang, Wenjun
中科院分区：
文献类型：
--
作者：
Cao, Jianqiao;Yang, Ting;Yang, Wenjun
目的：目的：分析2002年1月至2012年12月宁夏医科大学总医院收治的734例经胃镜及病理证实的回、汉族食管胃交界部腺癌（AEG）患者的临床病理特征及影响预后的因素。单因素和多因素分析的人口统计学，临床病理，预后data.Results：在总数，734 AEG患者接受手术干预，其中169回族患者和565汉族患者。回族患者的男女比例为9.5：1，汉族患者为6.4：1，两组患者的平均年龄约为61岁。汉族患者比回族患者更可能有吸烟史和饮酒史（58.8% vs. 29.4%，p = 0.000; 45.8% vs. 14.6%，p = 0.000）。回族和汉族患者的5年生存率分别为54.3%和39.9%（p = 0.024）。年龄（p = 0.005），性别（p = 0.015），病理T分期（p = 0.056），病理N分期（p = 0.000），病理M期（p = 0.001），切除的淋巴结数量（p = 0.001）和辅助放化疗结论：回、汉族AEG患者均以男性和老年人为主，回、汉族AEG患者预后好于汉族AEG患者。年龄、性别、病理T3-4分期、病理N分期、病理M分期、淋巴结切除数、辅助放化疗是两组AEG预后的独立预测因素。
Objective: To explore the clinicopathological features and prognostic factors of 734 cases of Chinese Hui and Han patients with adenocarcinoma of the esophagogastric junction (AEG).Methods: In total, 734 patients were confirmed to have AEG by gastroscopy and pathology at the General Hospital of Ningxia Medical University between January 2002 and December 2012. Univariate and multivariate analyses of demographic, clinicopathological, and prognostic data were performed.Results: In total, 734 AEG patients underwent surgical intervention, including 169 Hui patients and 565 Han patients. The male to female ratio was 9.5:1 in Hui patients and 6.4:1 in Han patients, and the average age in both groups was approximately 61 years. The Han patients were more likely to have a cigarette smoking history and an alcohol consumption history than the Hui patients (58.8% vs. 29.4%, p = 0.000; 45.8% vs. 14.6%, p = 0.000). The 5-year survival rate in the Hui and Han patients was 54.3% and 39.9%, respectively (p = 0.024). Age (p = 0.005), sex (p = 0.015), pathologic T stage (p = 0.056), pathologic N stage (p = 0.000), pathologic M stage (p = 0.001), number of resected lymph nodes (p = 0.001) and adjuvant chemoradiotherapy (p = 0.002) were significant independent prognostic factors.Conclusion: The AEG patients were primarily male and elderly in both Hui and Han groups with the prognosis of Hui patients better than Han patients. Age, sex, pathologic T3-4 stage, pathologic N stage, pathologic M stage, number of resected lymph nodes, and adjuvant chemoradiotherapy were significant independent factors predictive of the prognosis of AEG in both groups.