Lactation and risk of endometrial cancer in Japan: a case-control study.
Lactation and risk of endometrial cancer in Japan: a case-control study.
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DOI：
10.1620/tjem.208.109
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发表时间：
2006-01
期刊：
影响因子：
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通讯作者：
C. Okamura;Y. Tsubono;K. Ito;H. Niikura;T. Takano;S. Nagase;K. Yoshinaga;Y. Terada;T. Murakami-T.-Mu
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文献类型：
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作者：
C. Okamura;Y. Tsubono;K. Ito;H. Niikura;T. Takano;S. Nagase;K. Yoshinaga;Y. Terada;T. Murakami-T.-Mu
子宫内膜癌的发病率在日本迅速上升。尽管欧洲人群的危险因素已被很好地描述，但关于日本妇女子宫内膜癌危险因素的流行病学研究很少。这项以医院为基础的病例对照研究于1998年至2000年在日本妇女中进行。研究对象为子宫内膜癌患者（155例），对照组为在大学妇科门诊接受宫颈癌筛查的女性（96例）。研究人员对受试者进行了访谈，以确定母乳喂养习惯、避孕药具的使用情况以及子宫内膜癌的潜在危险因素。我们观察到与口服避孕药（OC）相关的子宫内膜癌风险较低，而与较高的体重指数（BMI）以及初产和末产年龄相关的子宫内膜癌风险较高。妊娠将子宫内膜癌的优势比（OR）降低至0.34（95%可信区间[CI] 0.13-0.92）。与从未母乳喂养的分娩妇女相比，有母乳喂养史妇女的多变量OR为0.37 （95% CI, 0.17-0.82）。此外，母乳喂养后较长的时间间隔使子宫内膜癌的OR增加了三倍以上。总之，目前的研究表明，母乳喂养可以降低日本女性患子宫内膜癌的风险。
The incidence of endometrial cancer is rapidly increasing in Japan. Although the risk factors in European populations have been well described, there are few epidemiologic studies regarding risk factors for endometrial cancer in Japanese women. This hospital-based case-control study among Japanese women was carried out from 1998 to 2000. The cases were selected from women with endometrial cancer (n =155), and the controls selected from women attending the university gynecological outpatient clinic for cervical cancer screening (n = 96). Subjects were interviewed to ascertain breast feeding practices, contraceptive usage, as well as potential risk factors for endometrial cancer. We observed a lower risk of endometrial cancer associated with oral contraceptive (OC) and a higher risk associated with higher body mass index (BMI), and older ages at first and last delivery. Gravidity reduced odds ratio (OR) for endometrial cancer to 0.34 (95% confidence interval [CI] 0.13-0.92). Compared with parous women who had never breastfed, the multivariate OR for women with a history of breastfeeding was 0.37 (95% CI, 0.17-0.82). Additionally, a greater lapse of time since breastfeeding increased OR for endometrial cancer by over three times. In conclusion, the present study has indicated that breastfeeding reduces the risk of endometrial cancer in Japanese women.