Delineation of the function of a major γδ T cell subset during infection
Delineation of the function of a major γδ T cell subset during infection
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DOI：
10.4049/jimmunol.175.3.1741
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发表时间：
2005-08-01
影响因子：
4.4
通讯作者：
Carding, SR
中科院分区：
文献类型：
--
作者：
Andrew, EM;Newton, DJ;Carding, SR
γ δ T细胞在病原体诱导的免疫反应和预防慢性炎症和病理中发挥重要但尚未明确的作用。定义其功能的一个主要障碍是确定γ δ T细胞之间功能冗余和异质性的程度。利用缺乏V γ γ 1(+) T细胞的小鼠（V γ γ 1(+) T细胞是γ δ T细胞对微生物感染反应的主要组成部分），已经建立了V γ γ 1(+) T细胞在感染期间巨噬细胞和γ δ T细胞稳态中的特异性免疫调节作用。相比之下，V γ 1(+) T细胞在病原体控制或根除中没有显著作用，不能保护小鼠免受免疫介导的病理。病原体诱导的V γ 1(+) T细胞在宿主对感染反应的不同阶段也表现出不同的功能特征，这涉及到独特和不同的V γ 1(+) T细胞群。因此，这些发现确定了γ δ T细胞亚群在感染中的独特且不重叠的作用，并确定了单个γ δ T细胞群体在宿主对感染的反应中的复杂性和适应性，这种反应不是预先确定的，而是由环境因素塑造的。
gamma delta T cells play important but poorly defined roles in pathogen-induced immune responses and in preventing chronic inflammation and pathology. A major obstacle to defining their function is establishing the degree of functional redundancy and heterogeneity among gamma delta T cells. Using mice deficient in V gamma 1(+) T cells which are a major component of the gamma delta T cell response to microbial infection, a specific immunoregulatory role for V gamma 1(+) T cells in macrophage and gamma delta T cell homeostasis during infection has been established. By contrast, V gamma 1(+) T cells play no significant role in pathogen containment or eradication and cannot protect mice from immune-mediated pathology. Pathogen-elicited V gamma 1(+) T cells also display different functional characteristics at different stages of the host response to infection that involves unique and different populations of V gamma 1(+) T cells. These findings, therefore, identify distinct and nonoverlapping roles for gamma delta T cell subsets in infection and establish the complexity and adaptability of a single population of gamma delta T cells in the host response to infection that is not predetermined, but is, instead, shaped by environmental factors.