Differentiation and function of Kupffer cells
Differentiation and function of Kupffer cells
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DOI：
10.1007/s00795-003-0228-x
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Yamamoto, Takashi
中科院分区：
文献类型：
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作者：
Naito, Makoto;Hasegawa, Go;Yamamoto, Takashi
库普弗细胞是最大的组织巨噬细胞群。它们主要分布在肝窦内，并对进入肝脏的血源性物质表现出内吞活性。巨噬细胞集落刺激因子和其他生长因子调节胎儿期和成年期的库普弗细胞分化。由于组织的独特属性，库普弗细胞不仅在宿主防御中发挥着重要作用，而且在组织的稳态反应中也发挥着重要作用。巨噬细胞清道夫受体和血红素加氧酶在个体发育早期阶段的库普弗细胞中表达。清道夫受体不仅参与脂质代谢，还参与杀菌机制。库普弗细胞中的血红素加氧酶对于胆红素的产生至关重要。在这篇综述中，描述了库普弗细胞的发育机制和功能活动。有证据表明库普弗细胞代表了一个独特的细胞群，具有独特的分化机制、代谢功能和对炎症因子的反应。
Kupffer cells are the largest population of tissue macrophages. They are predominantly distributed in the lumen of hepatic sinusoids and exhibit endocytic activity against blood-borne materials entering the liver. Macrophage colony-stimulating factor and other growth factors regulate Kupffer cell differentiation in the fetal and adult period. Because of the unique attributes of tissue, Kupffer cells play essential roles not only in host defense but also in the homeostatic responses of tissue. Macrophage scavenger receptors and heme oxygenase are expressed in Kupffer cells from an early stage of ontogeny. Scavenger receptors are involved not only in the lipid metabolism but also in the bactericidal mechanism. Heme oxygenase in Kupffer cells is essential to the production of bilirubin. In this review, the developmental mechanism and functional activities of Kupffer cells are described. Evidence suggests that Kupffer cells represent a distinct cell population with unique differentiation mechanisms, metabolic functions, and responsiveness to inflammatory agents.