Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines.
Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines.
复制标题
识别 CD1 的转基因 T 细胞亚群诱导或预防小鼠狼疮：细胞因子的作用。
DOI：
10.1084/jem.187.4.525
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Strober,S
中科院分区：
文献类型：
--
作者：
Zeng,D;Dick,M;Cheng,L;Amano,M;Dejbakhsh-Jones,S;Huie,P;Sibley,R;Strober,S
具有识别同系B细胞上的CD 1的T细胞受体（TCR）转基因的T细胞在体外刺激B细胞分泌免疫球蛋白。TCR转基因BALB/c供体脾脏中的CD 4、CD 8或CD 4 CD 8 T细胞在用裸骨髓重建的辐照BALB/c裸小鼠中诱导狼疮伴抗双链DNA抗体、蛋白尿和免疫复合物肾小球肾炎。从转基因供体的骨髓中注射纯化的CD 4 CD 8 T细胞可以防止转基因T细胞诱导狼疮。诱导狼疮的转基因T细胞分泌大量的干扰素（IFN）-和少量的白细胞介素（IL）-4，而那些预防狼疮的T细胞分泌大量的IL-4和少量的IFN-或IL-10。
T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4, CD8, or CD4 CD8 T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti–double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4 CD8 T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)-and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN-or IL-10.