STRESSOR INVOKED EXACERBATION OF AMPHETAMINE-ELICITED PERSEVERATION
STRESSOR INVOKED EXACERBATION OF AMPHETAMINE-ELICITED PERSEVERATION
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DOI：
10.1016/0091-3057(85)90552-0
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发表时间：
1985-01-01
影响因子：
3.6
通讯作者：
ZACHARKO, RM
中科院分区：
文献类型：
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作者：
ANISMAN, H;HAHN, B;ZACHARKO, RM
在Y迷宫中，苯丙胺诱导的刺激保存刺激在暴露于不可控电击的动物中显著增强，而可控电击不影响操作。无论是立即施加应激源还是在持续性测试前72小时施加应激源，只要提供电击的刺激复合体与持续性测试的刺激复合体相似，刺激持续性的增强都是明显的。当两种环境明显不同时，电击后即刻刺激持续力增强明显，而电击后72小时则不明显。研究表明，应激源可能具有安非他明诱导的持之以恒的长期影响，但这种影响的表达取决于对行为进行检查的刺激环境。此外，有人建议，评估安非他明诱导的行为变化，以及可能的安非他明诱导的和特发性精神病，应该考虑有机体的应激史。
The provocation of stimulus preservation induced by amphetamine in a Y-maze was appreciably enhanced in animals that had been exposed to uncontrollable shock, whereas controllable shock did not influence performance. The enhancement of the stimulus perseveration was evident irrespective of whether the stressor was applied immediately or 72 h prior to the perseveration test, provided that the stimulus complex in which shock was delivered was similar to that in which the perseveration test was conducted. When the two environments were distinctively different from one another the enhancement of stimulus perseveration was evident immediately after shock exposure, but not 72 h after shock. It is suggested that stressors may have long-term effects of amphetamine-elicited perseveration, but the expression of such an effect is dependent upon the stimulus context in which the behavior is examined. Moreover, it is suggested that evaluation of amphetamine-induced behavioral changes, and possibly amphetamine-elicited and idiopathic psychosis, should consider the stress history of the organism.