Monoamine oxidase inhibitors. A review of antidepressant effectiveness.
Monoamine oxidase inhibitors. A review of antidepressant effectiveness.
复制标题
单胺氧化酶抑制剂。
DOI：
10.1001/archpsyc.1979.01780070027003
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发表时间：
1979
影响因子：
--
通讯作者：
S. Pelton
中科院分区：
文献类型：
--
作者：
J. Davidson;S. Pelton
来自单胺氧化酶（MAO）抑制剂的双盲、安慰剂对照试验的数据表明，苯乙肼对神经症或非典型抑郁症明显有效，但关于其对内源性抑郁症的影响的研究结果尚不确定。虽然反苯环丙胺的对照研究很少，但也有类似的结论。研究对比了MAO抑制剂和三环类抗抑郁药（TCA），以获得有关可能对MAO抑制剂有反应的患者类型的进一步信息。我们认为，简单地对比TCA和MAO抑制剂的相对疗效已经过时。神经症性或非典型抑郁症可能是一种异质性综合征，需要描述对特定抗抑郁药有反应的亚型。本文讨论了快速乙酰化、选择性单胺氧化酶抑制剂、单胺氧化酶A和单胺氧化酶B类型以及血小板单胺氧化酶抑制措施的意义。
Data from double-blind, placebo-controlled trials of the monoamine oxidase (MAO) inhibitors show that phenelzine is clearly effective in neurotic or atypical depressives, but the findings concerning its effect in endogenous depressives are inconclusive. Although few controlled studies have been done with tranylcypromine, similar conclusions are warranted. Studies have contrasted MAO inhibitors and tricyclic antidepressants (TCAs) to gain further information about the type of patients likely to respond to MAO inhibitors. We believe that simply contrasting the relative efficacy of TCAs and MAO inhibitors is outdated. Neurotic or atypical depression is probably a heterogeneous syndrome, and delineation of subtypes responsive to specific antidepressants is needed. The implications of fast acetylation, selective MAO inhibitors, types MAOA and MAOB, and measures of platelet MAO inhibition are discussed in this article.