Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients
Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's disease patients
复制标题
DOI：
10.1128/jcm.38.2.881-882.2000
复制
发表时间：
2000-02-01
影响因子：
9.4
通讯作者：
Maass, M
中科院分区：
文献类型：
--
作者：
Gieffers, J;Reusche, E;Maass, M
最近北美的一项研究在19名阿尔茨海默氏症患者的大脑中检测到17名肺炎衣原体，并推测C。肺炎感染是阿尔茨海默病（AD）的危险因素。在这项研究中，我们分析了20例AD患者的石蜡包埋组织样本，通过巢式PCR和免疫细胞化学与一组抗衣原体抗体，不能检测到C。肺炎克雷伯氏菌特异性DNA和衣原体抗原;肺炎在阿尔茨海默氏症患者的大脑中并不是一种常见的现象;相关性仍然值得怀疑。
A recent North American study detected Chlamydia pneumoniae in 17 of 19 brains of Alzheimer's patients and supposed a C. pneumoniae infection to be a risk factor for Alzheimer's disease (AD). In this study, we analyzed paraffin-embedded tissue samples of 20 AD patients by nested PCR and immunocytochemistry with a panel of antichlamydial antibodies and could detect neither C. pneumoniae-specific DNA nor chlamydial antigens; From our data, the presence of C. pneumoniae in the brains of Alzheimer's patients is not a common phenomenon; an association remains questionable.