Murine renal allografts: Spontaneous acceptance is associated with regulated T cell-mediated immunity
Murine renal allografts: Spontaneous acceptance is associated with regulated T cell-mediated immunity
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DOI：
10.4049/jimmunol.167.9.4821
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发表时间：
2001-11-01
影响因子：
4.4
通讯作者：
Orosz, CG
中科院分区：
文献类型：
--
作者：
Bickerstaff, AA;Wang, JJ;Orosz, CG
20年前的研究表明，在没有免疫抑制的情况下，小鼠会自发接受同种异体肾移植，但导致这一现象的机制尚不清楚。我们将DBA/2(H-2(D))肾移植到肾切除的C57BL/6(H-2(B))小鼠体内，并在没有免疫抑制的情况下自发接受同种异体移植60天。相反，同一菌株组合中的非免疫抑制同种异体心脏和皮肤移植在大约10天内被排斥。接受的同种异体肾移植有明显的白细胞渗入，提示有持续的局部免疫反应。移植后60天，接受同种异体肾移植的受者出现DBA/2反应性同种异体抗体。它们还表现出DBA/2反应性迟发性超敏反应，这些反应可被DBA/2诱导的转化生长因子-β的产生积极地反调节，但不受IL-10的产生的调节。这些数据表明，一种涉及转化生长因子-β的供者反应性、细胞介导的免疫机制与小鼠移植肾的自发接受有关。
It was shown > 20 yr ago that mice will spontaneously accept renal allografts in the absence of immunosuppression, but the mechanism responsible for this Is not understood. We transplanted DBA/2 (H-2(d)) kidneys into nephrectomized C57BL/6 (H-2(b)) mice, and the allografts were spontaneously accepted for > 60 days without immunosuppression. In contrast, nonimmunosuppressed cardiac and skin allografts in the same strain combination are rejected within approximately 10 days. The accepted renal allografts have a prominent leukocytic infiltrate, suggesting an ongoing, local immune response. At 60 days post-transplant, the recipients of accepted renal allografts display DBA/2-reactive alloantibodies. They also display DBA/2-reactive delayed-type hypersensitivity responses that are actively counter-regulated by DBA/2-induced TGF-beta production, but not by IL-10 production. These data suggest that a donor-reactive, cell-mediated immune mechanism involving TGF-beta is associated with the spontaneous acceptance of renal allografts In mice.