Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis
Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis
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DOI：
10.3892/mco.2015.617
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发表时间：
2015-11-01
影响因子：
1.2
通讯作者：
Dai, Zhi-Jun
中科院分区：
文献类型：
--
作者：
Ren, Hongtao;Ma, Hongbing;Dai, Zhi-Jun
Flap 核酸内切酶-1 (FEN1) 是维持基因组稳定性和防止肿瘤发生的关键因素。自从鉴定出 FEN1（rs174538 和 rs4246215）的功能多态性以来，大量研究评估了这两种单核苷酸多态性与癌症风险之间的关联。为了获得更精确的估计，对 FEN1 多态性（rs174538 和 rs4246215）与癌症风险之间的关联进行了荟萃分析。使用比值比 (OR) 和 95% 置信区间 (CI) 来估计关联的强度。确定了 13 项病例对照研究，包括 5,108 例病例和 6,382 例无病例对照。对于 rs174538，与 -69AA 基因型相比，具有 GG 或 GA 基因型的个体患癌症的风险增加（AA 与 GG：OR，1.85；95% CI，1.65-2.08；P
Flap endonuclease-1 (FEN1) is a key factor during the maintenance of genomic stability and protection against tumorigenesis. Since the identification of functional polymorphisms of FEN1 (rs174538 and rs4246215), numerous studies have evaluated the association between the two single-nucleotide polymorphisms and cancer risk. To derive a more precise estimation, a meta-analysis was performed on the association between the FEN1 polymorphisms (rs174538 and rs4246215) and cancer risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of the associations. Thirteen case-control studies, including 5,108 cases and 6,382 case-free controls, were identified. For rs174538, individuals with the GG or GA genotype had an increased risk of cancer when compared to the -69AA genotype (AA vs. GG: OR, 1.85; 95% CI, 1.65-2.08; P