Polyketides from Mantis-Associated Fungus Daldinia eschscholzii IFB-TL01
Polyketides from Mantis-Associated Fungus Daldinia eschscholzii IFB-TL01
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来自螳螂相关真菌 Daldinia eschscholzii IFB-TL01 的聚酮化合物
DOI：
10.1002/cbdv.201400414
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发表时间：
2015-09-01
影响因子：
2.9
通讯作者：
Tan, Ren-Xiang
中科院分区：
文献类型：
--
作者：
Wang, Gang;Fan, Jing-Yang;Tan, Ren-Xiang
从 Daldinia eschscholzii 培养物中分离出三种新的聚酮化合物，分别命名为 daldinone F (1)、nodulisporin G (2) 和 dalmanol C (3)，以及五种已知化合物 4-8。通过广泛的核磁共振和质谱分析阐明了新化合物的结构。化合物1对SW480癌细胞表现出中等的细胞毒活性，IC50值为9.59μM，其绝对构型通过单晶X射线衍射测定。
Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4-8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 mu M, and its absolute configuration was determined by single crystal X-ray diffraction.