SUPPRESSIVE EFFECT OF A NEUTROPHIL ELASTASE INHIBITOR ON THE DEVELOPMENT OF COLLAGEN-INDUCED ARTHRITIS
SUPPRESSIVE EFFECT OF A NEUTROPHIL ELASTASE INHIBITOR ON THE DEVELOPMENT OF COLLAGEN-INDUCED ARTHRITIS
复制标题
DOI：
10.1006/cimm.1995.1183
复制
发表时间：
1995-10-01
影响因子：
4.3
通讯作者：
NAKAMURA, H
中科院分区：
文献类型：
--
作者：
KAKIMOTO, K;MATSUKAWA, A;NAKAMURA, H
本研究以Ⅱ型胶原免疫的BB/DR大鼠和DBA/1小鼠为模型，观察了一种新型的中性粒细胞弹性蛋白酶抑制剂ONO-5046对胶原诱导的类风湿性关节炎（collagen-induced arthritis，CA）的影响。ONO-5046降低大鼠和小鼠CA的发病率以及严重程度。这种对严重程度的抑制作用与组织学结果的改善相关，特别是与关节软骨破坏的减少相关。提示中性粒细胞弹性蛋白酶在CA的发病中可能起重要作用。(C)出版社：Academic Press
A novel neutrophil elastase inhibitor, ONO-5046, was administered to BB/DR rats and DBA/1 mice immunized with type II collagen to study its effect on the development of collagen-induced arthritis (CA), an experimental model of human rheumatoid arthritis. ONO-5046 reduced the incidence as well as the severity of CA in both rats and mice. This suppressive effect on severity was correlated with improvement of the histological findings, particularly with reduced destruction of the articular cartilage. These results indicate that neutrophil elastase may play an important role in the pathogenesis of CA. (C) 1995 Academic Press, Inc.