Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration.
Biphasic organo-bioceramic fibrous composite as a biomimetic extracellular matrix for bone tissue regeneration.
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DOI：
10.2741/e795
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发表时间：
2017-03-01
期刊：
影响因子：
--
通讯作者：
Mishra MK
中科院分区：
文献类型：
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作者：
Kumar S;Stokes JA III;Dean D;Rogers C;Nyairo E;Thomas V;Mishra MK
In bone tissue engineering, the organo-ceramic composite, electrospun polycaprolactone/hydroxyapatite (PCL/HA) scaffold has the potential to support cell proliferation, migration, differentiation, and homeostasis. Here, we report the effect of PCL/HA scaffold in tissue regeneration using human mesenchymal stem cells (hMSCs). We characterized the scaffold by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscope (SEM) and assessed its biocompatibility. PCL/HA composite is superior as a scaffold compared to PCL alone. Furthermore, increasing HA content (5–10%) was more efficacious in supporting cell-scaffold attachment, expression of ECM molecules and proliferation. These results suggest that PCL/HA is useful as a scaffold for tissue regeneration.
