Association of Resting Heart Rate with Infrarenal Aortic Diameter: A Cross Sectional Study in Chinese Hypertensive Adults
Association of Resting Heart Rate with Infrarenal Aortic Diameter: A Cross Sectional Study in Chinese Hypertensive Adults
复制标题
DOI：
10.1016/j.ejvs.2015.05.022
复制
发表时间：
2015-12-01
影响因子：
5.7
通讯作者：
Huo, Y.
中科院分区：
文献类型：
--
作者：
Wei, R.;Liu, L. S.;Huo, Y.
目的：静息心率（RHR）升高已被证明是心血管疾病的危险标志。从RHR在大动脉的影响的研究结果仅限于这些动脉的功能变化，而RHR和主动脉直径之间的关联仍然在很大程度上understudied.Methods：这是一个横断面研究的高血压中国成年人从农村地区。通过超声测量肾动脉至髂动脉分叉处的最大肾下主动脉直径（maxIAD）。由于性别之间存在显著差异，因此分别在男性和女性中比较不同RHR组的MaxIAD。多元回归分析RHR与maxIAD的相关性。三个因素（BMI，吸烟和抗高血压方案）和最大IAD的RHR之间的进一步相互作用进行了检查使用亚组analysis.Results：19,200名受试者参加了这项研究，平均年龄为64.8 +/- 7.4岁，61.6%的女性。仅22例（0.11%）被检测到AAA，男性（n = 17）的AAA发生率高于女性（n = 5）。在≥ 65岁的受试者中，有18例（0.19%）AAA，15例（83.3%）有吸烟史。在所有受试者中，平均最大IAD范围为15.7 +/- 2.1 mm至15.2 +/- 2.2 mm，男性RHR从最低四分位数变为最高（>= 84 bpm），女性中观察到类似趋势。RHR与maxIAD的相关系数男性为0.17，女性为0.12。进一步的亚组分析显示，吸烟夸大了RHR和maxIAD之间的相关性，但只在females.Conclusions：AAA的发病率低，观察在这个高血压中国人群。RHR和maxIAD之间存在负相关，可能被吸烟夸大，尤其是女性。(C)2015年由Elsevier Ltd代表欧洲血管外科学会发表。
Objective: Elevated resting heart rate (RHR) has been shown to be a risk marker for cardiovascular disease. Results from studies on the effects of RHR in large arteries are limited to the functional changes of those arteries, while the association between RHR and aortic diameter remains largely understudied.Methods: This was a cross sectional study of hypertensive Chinese adults from-rural areas. The maximum infrarenal aortic diameter (maxIAD) from renal arteries to the iliac bifurcation was obtained by ultrasound. MaxIADs in different RHR groups were compared in males and females separately because of the significant differences between sexes. Multiple regression analysis was used to determinate the correlation between RHR and maxIAD. Further interactions between three factors (BMI, smoking, and anti-hypertensive regimens) and RHR for maxIAD were examined using subgroup analysis.Results: 19,200 subjects were enrolled in the study, with an average age of 64.8 +/- 7.4 years and 61.6% females. Only 22 cases (0.11%) were detected with AAA, with males (n = 17) presenting a higher AAA incidence than females (n = 5). In subjects >= 65 years, there were 18 (0.19%) AAA, and 15 (83.3%) had a history of smoking. In the total subjects, the mean maxIAD ranged from 15.7 +/- 2.1 mm to 15.2 +/- 2.2 mm as RHR changed from the lowest quartile to the highest (>= 84 bpm) in males, with a similar tendency observed in females. The correlation coefficient of RHR on maxIAD was 0.17 in males and 0.12 in females. Further subgroup analysis revealed that smoking exaggerated the correlation between RHR and maxIAD, but only in females.Conclusions: A low AAA incidence was observed in this hypertensive Chinese population. There was a negative association between RHR and maxIAD, potentially exaggerated by smoking, especially in females. (C) 2015 Published by Elsevier Ltd on behalf of European Society for Vascular Surgery.