Effects of endothelin on regional hemodynamics in conscious rats.
Effects of endothelin on regional hemodynamics in conscious rats.
复制标题
内皮素对清醒大鼠局部血流动力学的影响。
DOI：
10.1016/0014-2999(89)90162-3
复制
发表时间：
1989
影响因子：
5
通讯作者：
Knuepfer,MM
中科院分区：
文献类型：
--
作者：
Han,SP;Trapani,AJ;Fok,KF;Westfall,TC;Knuepfer,MM
内皮素是麻醉大鼠和分离的血管平滑肌中的一种有效的血管活性多肽。本研究旨在观察内皮素对清醒自由活动大鼠血流动力学的影响。内皮素(0.067-2nmol/kg静脉注射)导致动脉压、肠系膜压持续、剂量依赖性增加，以及较轻程度的后肢血管阻力增加和心率下降。我们认为，内皮素可能通过调节外周血管舒缩张力而在调节动脉压中发挥重要作用。
Endothelin is a potent vasoactive peptide in anesthezed rats and isolated vascular smooth muscle. This study was performed to describe the hemodynamic effects of endothelin in conscious, freely moving rats. Endothelin (0.067-2 nmol/kg i.v.) produced long-lasting, dose-dependent increases in arterial pressure, mesenteric and, to a lesser degree, hindquarters vascular resistances and decreases in heart rate. We suggest that endothelin may play an important role in regulation of arterial pressure by modulating peripheral vasomotor tone.