Renalase rs10887800 polymorphism is associated with severe pre-eclampsia in southeast Iranian women
Renalase rs10887800 polymorphism is associated with severe pre-eclampsia in southeast Iranian women
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肾酶 rs10887800 多态性与伊朗东南部妇女重度子痫前期有关
DOI：
10.1002/jcb.27595
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发表时间：
2019-03-01
影响因子：
4
通讯作者：
Salimi, Saeedeh
中科院分区：
文献类型：
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作者：
Teimoori, Batool;Moradi-Shahrebabak, Maryam;Salimi, Saeedeh
有证据表明，先兆子痫（PE）与儿茶酚胺水平升高有关。肾酶是一种儿茶酚胺代谢酶，会导致高血压的发生。在本研究中，我们旨在评估两个肾酶基因（RNLS）多态性之间的关系，包括5'侧翼区域的rs2576178和内含子6（靠近外显子/内含子边界）的rs10887800与PE易感性之间的关系。在这项病例对照研究中，通过聚合酶链反应-限制性片段长度多态性方法对179名PE女性和202名血压正常孕妇进行RNLS rs2576178和rs10887800多态性基因分型。 RNLS rs10887800 和 rs2576178 多态性与 PE 之间没有关联，无论是在显性模型还是隐性模型中。尽管 RNLS rs10887800 多态性与轻度 PE 之间没有关联，但在隐性模型中，这种多态性与 2.2 倍的严重 PE 风险相关（比值比 [OR]，2.2；95% 置信区间 [CI]，1.2-4.4；P = 0.01），但在显性模型中则不然。 RNLS rs2576178 和 rs10887800 多态性与 PE 严重程度无关。 RNLS rs10887800 和 rs2576178 GG/GG 组合基因型分别与 PE 和严重 PE 的风险升高 8.4 倍和 16.7 倍相关（OR，8.4；95% CI，1-71.1；P = 0.048 和 OR，16.7；95% CI，1.6-167；P = 0.018）。此外，G-G 单倍型与 1.7 倍的 PE 和轻度 PE 风险相关（OR，1.7；95% CI，1.1-2.4；P = 0.009 和 OR，1.7；95% CI，1.1-2.5；P = 0.02）。 RNLS rs10887800 多态性与严重 PE 相关。 RNLS rs10887800 和 rs2576178 GG/GG 组合基因型和 G-G 单倍型与较高的 PE 风险相关。
Evidence has shown that pre-eclampsia (PE) is associated with an increased level of catecholamines. Renalase is a catecholamine-metabolizing enzyme, which contributes to the occurrence of hypertension. In the current study, we aimed to assess the relation between two renalase gene (RNLS) polymorphisms, including rs2576178 at the 5 '-flanking region and rs10887800 at intron 6, near the exon/intron border and PE susceptibility. In this case-control study, 179 women with PE and 202 normotensive pregnant women were genotyped for RNLS rs2576178 and rs10887800 polymorphisms by the polymerase chain reaction-restriction fragment length polymorphism method. There was no association between RNLS rs10887800 and rs2576178 polymorphisms and PE, neither in the dominant nor in the recessive model. Although there was no association between RNLS rs10887800 polymorphism and mild PE, this polymorphism was associated with 2.2-fold higher risk of severe PE in the recessive model (odds ratio [OR], 2.2; 95% confidence interval [CI], 1.2-4.4; P = 0.01) but not in the dominant model. The RNLS rs2576178 and rs10887800 polymorphisms were not associated with PE severity. The RNLS rs10887800 and rs2576178 GG/GG combined genotypes were associated with 8.4- and 16.7-fold higher risk of PE and severe PE, respectively (OR, 8.4; 95% CI, 1-71.1; P = 0.048 and OR, 16.7; 95% CI, 1.6-167; P = 0.018). Also, the G-G haplotype was associated with 1.7-fold risk of PE and mild PE (OR, 1.7; 95% CI, 1.1-2.4; P = 0.009 and OR, 1.7; 95% CI, 1.1-2.5; P = 0.02). The RNLS rs10887800 polymorphism was associated with severe PE. The RNLS rs10887800 and rs2576178 GG/GG combined genotypes and G-G haplotype were associated with higher risk of PE.