Synthesis, characterization and the formation mechanism of magnesium- and strontium-substituted hydroxyapatite
Synthesis, characterization and the formation mechanism of magnesium- and strontium-substituted hydroxyapatite
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镁、锶取代羟基磷灰石的合成、表征及形成机制
DOI：
10.1039/c4tb02148g
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发表时间：
2015-01-01
影响因子：
7
通讯作者：
Yang, Xianjin
中科院分区：
文献类型：
--
作者：
Geng, Zhen;Cui, Zhenduo;Yang, Xianjin
镁（Mg）和锶（Sr）因其优异的生物活性而被广泛应用于植入器械领域。然而，种植体引起的局部高离子浓度影响了骨和牙齿的主要无机成分羟基磷灰石（Ca-10(PO4)(6)(OH)(2)，HA）的生长。许多研究调查了Mg2+和Sr2+对HA生长的影响，但尚未进行系统研究来比较这两种离子对HA生长的影响。在这项研究中，通过传统的水热方法进行了一系列Sr-和Mg-取代的HA的取代。采用X射线衍射、电感耦合等离子体、场发射扫描电子显微镜、透射电子显微镜、选区电子衍射、热重-差示扫描量热法和傅里叶变换红外光谱等综合表征技术，研究了Sr2+和Mg2+对HA的物相、形貌、结晶度、化学成分、热稳定性和晶格参数的影响。结果表明，Mg离子部分取代了磷灰石结构中的钙(Ca)离子，从而降低了晶格参数，部分吸附在磷灰石表面形成非晶相，抑制了晶体生长。相比之下，Sr离子完全取代了Ca离子并增加了晶格参数。 Mg 和 Sr 离子均影响 HA 的形貌。结晶度随着Mg离子的添加而降低（从晶相到非晶相的转变发生在30%~40% Mg之间），但不受Sr离子的影响。热稳定性随着 Mg 的添加而降低（总重量损失从 10% Mg 的 8.06 wt% 降至 50% Mg 的 25.81 wt%），但在 Sr 取代的样品中没有显着变化。
Magnesium (Mg) and strontium (Sr) have been widely used in the field of implanted devices because of their excellent bioactivity. However, the local high ion concentration caused by the implant affects the growth of hydroxyapatite (Ca-10(PO4)(6)(OH)(2), HA), which is the main inorganic component of bone and teeth. Many studies have investigated the effect of Mg2+ and Sr2+ on the growth of HA, but no systematic research has been conducted to compare these two ions in terms of the growth of HA. In this study, the substitution of a series of Sr- and Mg-substituted HA was conducted through a conventional hydrothermal method. Comprehensive characterization techniques, including X-ray diffraction, inductive coupled plasma, field emission scanning electron microscopy, transmission electron microscopy, selected-area electron diffraction, thermo gravimetric-differential scanning calorimetry, and Fourier transform infrared spectroscopy, were used to examine the effects of Sr2+ and Mg2+ on the phase, morphology, crystallinity, chemical composition, thermal stability, and lattice parameters of HA. The results indicated that Mg ions partially substituted for calcium (Ca) ions in the apatite structure, thus decreasing the lattice parameters, partially adsorbing on the apatite surface that formed the amorphous phase, and inhibiting the crystal growth. By contrast, Sr ions fully substituted for Ca ions and increased the lattice parameters. Both Mg and Sr ions affected the morphology of HA. Crystallinity decreased with the addition of Mg ions (transition from the crystal to amorphous phase was between 30% and 40% Mg), but it was not affected by Sr ions. Thermostability decreased with the addition of Mg (a total weight loss from 8.06 wt% for 10% Mg to 25.81 wt% for 50% Mg), but it had no significant changes in the Sr-substituted samples.