Cyclin G2: A novel independent prognostic marker in pancreatic cancer
Cyclin G2: A novel independent prognostic marker in pancreatic cancer
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DOI：
10.3892/ol.2015.3667
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发表时间：
2015-11-01
期刊：
影响因子：
2.9
通讯作者：
Ishii, Hideshi
中科院分区：
文献类型：
--
作者：
Hasegawa, Shinichiro;Nagano, Hiroaki;Ishii, Hideshi
与其他正调控细胞周期的细胞周期蛋白不同，细胞周期蛋白G2（CCNG 2）作为肿瘤抑制基因调控细胞增殖。CCNG 2表达降低可作为几种类型癌症预后不良的标志。本研究的目的是阐明胰腺癌患者中CCNG 2表达与总生存率和组织病理学因素的相关性。该回顾性分析包括36例连续患者的数据，这些患者接受了胰腺癌完全手术切除，未接受任何术前治疗。采用免疫组化染色法检测乳腺癌组织中CCNG 2的表达。多因素分析表明CCNG 2的表达是影响胃癌预后的独立因素。此外，总生存期的Kaplan-Meier曲线显示，CCNG 2表达降低是胰腺癌患者预后不良的一致指标（P=0.0198）。CCNG 2表达下降与肿瘤标本的静脉浸润和肿瘤浸润深度显着相关。总之，CCNG 2表达与癌症进展呈负相关，可能是胰腺癌中一种新的独立预后标志物。
Unlike other cyclins that positively regulate the cell cycle, cyclin G2 (CCNG2) regulates cell proliferation as a tumor suppressor gene. A decreased CCNG2 expression serves as a marker for poor prognosis in several types of cancer. The aim of the present study was to clarify the correlation of CCNG2 expression with overall survival and histopathological factors in pancreatic cancer patients. This retrospective analysis included data from 36 consecutive patients who underwent complete surgical resection for pancreatic cancer and did not undergo any preoperative therapies. The association between prognoses and the expression of CCNG2 was assessed using immunohistochemical staining. Multivariate analysis identified that the expression of CCNG2 is an independent prognostic factor. In addition, the Kaplan-Meier curve for overall survival revealed that decreased expression of CCNG2 was a consistent indicator of poor prognosis in pancreatic cancer patients (P=0.0198). A decreased CCNG2 expression significantly correlated with venous invasion in tumor specimens and the tumor invasion depth. In conclusion, CCNG2 expression inversely reflected cancer progression and may be a novel, independent prognostic marker in pancreatic cancer.