Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies.
Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies.
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DOI：
10.1161/circulationaha.113.005925
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发表时间：
2014-02-11
期刊：
影响因子：
37.8
通讯作者：
Hu FB
中科院分区：
文献类型：
--
作者：
Ding M;Bhupathiraju SN;Satija A;van Dam RM;Hu FB
关于咖啡消费与心血管疾病(CVD)风险之间的关联，存在着相当大的争议。通过荟萃分析评估长期饮用咖啡与心血管疾病风险之间的剂量-反应关系。PubMed和EMBASE被搜索到关于咖啡消费与心血管疾病风险之间关系的前瞻性队列研究，其中包括冠心病、中风、心力衰竭和心血管疾病死亡率。36项研究包括1,279,804名参与者和36,352例心血管疾病病例。咖啡消费量与心血管疾病风险之间存在非线性关系(异质性P=0.09，趋势P=0.001，非线性P=0.001)。与咖啡消费量最低的类别(中位数：0杯/d)相比，最高类别(中位数：5杯/d)患心血管疾病的相对风险为0.95(95%CI，0.87至1.03)，第二高类别(中位数：3.5杯/d)的相对风险为0.85(0.80至0.90)，第三高类别(中位数：1.5杯/d)的相对风险为0.89(0.84至0.94)。从不同的结果来看，喝咖啡与冠心病(异质性P=0.001，趋势性P=0.001，非线性P=0.001)和中风风险(P=0.07，P=0.001，P=0.001)和中风风险(趋势差异P>0.05)呈非线性相关。在这项荟萃分析中观察到咖啡摄入量与心血管疾病风险之间的非线性关联。适量饮用咖啡与心血管疾病风险呈显著负相关，每天饮用3至5杯咖啡的心血管风险最低，而大量饮用咖啡与心血管疾病风险增加无关。
Considerable controversy exists regarding the association between coffee consumption and cardiovascular disease (CVD) risk. A meta-analysis was performed to assess the dose-response relationship of long-term coffee consumption with CVD risk. Pubmed and EMBASE were searched for prospective cohort studies of the relationship between coffee consumption and CVD risk, which included coronary heart disease, stroke, heart failure, and CVD mortality. Thirty-six studies were included with 1,279,804 participants and 36,352 CVD cases. A non-linear relationship of coffee consumption with CVD risk was identified (P for heterogeneity = 0.09, P for trend < 0.001, P for non-linearity < 0.001). Compared with the lowest category of coffee consumption (median: 0 cups/d), the relative risk of CVD was 0.95 (95% CI, 0.87 to 1.03) for the highest (median: 5 cups/d) category, 0.85 (0.80 to 0.90) for the second highest (median: 3.5 cups/d), and 0.89 (0.84 to 0.94) for the third highest category (median: 1.5 cups/d). Looking at separate outcomes, coffee consumption was non-linearly associated with both CHD (P for heterogeneity = 0.001, P for trend < 0.001, P for non-linearity < 0.001) and stroke risks (P for heterogeneity = 0.07, P for trend < 0.001, P for non-linearity< 0.001) (P for trend differences > 0.05). A non-linear association between coffee consumption with CVD risk was observed in this meta-analysis. Moderate coffee consumption was inversely significantly associated with CVD risk, with the lowest CVD risk at 3 to 5 cups/d, and heavy coffee consumption was not associated with elevated CVD risk.