Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole
Delivery outcome after the use of acid-suppressing drugs in early pregnancy with special reference to omeprazole
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DOI：
10.1111/j.1471-0528.1998.tb10233.x
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发表时间：
1998-08-01
期刊：
影响因子：
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通讯作者：
Kallen, B
中科院分区：
文献类型：
--
作者：
Kallen, B
目的研究孕妇在妊娠早期使用抑酸药物后的分娩结局。设计队列研究，通过对1995年至1997年早期瑞典分娩妇女的访谈确定妊娠早期妇女。方法比较1995年至1997年期间接触抑酸药物的婴儿与所有分娩的婴儿。结果275名妇女使用质子泵阻滞剂，255名妇女使用H-2受体拮抗剂，20名妇女使用两种药物。使用奥美拉唑或H-2-受体拮抗剂对先天性畸形率没有影响，可以证明，结论虽然这些药物的致畸作用不能完全排除，暴露后的个人风险在孕早期似乎可以忽略不计。
Objective To study delivery outcome after maternal use of acid-suppressing drugs during early pregnancy.Design Cohort study of women identified by interview in early pregnancy.Population Sweden women giving birth from 1995 to early 1997.Methods Comparison of infants exposed to acid-suppressing drugs with all births in 1995-1996.Main outcome measures Presence of congenital malformations.Results Proton pump blockers were used by 275 women, H-2 receptor antagonists by 255 women, and both categories of drugs by 20 women. No effect of the use of omeprazole or H-2-receptor antagonists on the rate of congenital malformations could be demonstrated.Conclusions Though a teratogenic effect of these drugs cannot be completely ruled out, the individual risk after exposures during the first trimester seems to be negligible.