γ-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms
γ-tocopherol induces apoptosis in androgen-responsive LNCaP prostate cancer cells via caspase-dependent and independent mechanisms
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DOI：
10.1196/annals.1331.056
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Ames, BN
中科院分区：
文献类型：
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作者：
Jiang, Q;Wong, J;Ames, BN
我们发现-生育酚是饮食中主要的维生素E形式，而α -生育酚是大多数补充剂中维生素E的唯一形式，它对前列腺（PC-3, LNCaP）和肺（A549）癌细胞具有抗增殖作用。γ -生育酚诱导雄激素敏感的LNCaP细胞凋亡，而雄激素抗性的PC-3细胞不凋亡。因此，γ -生育酚处理导致细胞色素c释放和caspase-9、-3和-7活化。然而，不可逆的pancaspase抑制剂不能完全逆转细胞凋亡，这表明另一种不依赖caspase的途径也可能参与其中。我们的研究表明-生育酚在预防和治疗某些类型的癌症方面可能是有价值的。
We found that gamma-tocopherol, the predominant vitamin E form in diets, but not alpha-tocopherol, which is the exclusive form of vitamin E in most supplements, exhibited antiproliferation effect on prostate (PC-3, LNCaP) and lung (A549) cancer cells. gamma-Tocopherol induced apoptosis in androgen-sensitive LNCaP but not androgen-resistant PC-3 cells. Consequently, gamma-tocopherol treatment caused cytochrome c release and caspase-9, -3 and -7 activation. However, the apoptosis could not be completely reversed by an irreversible pancaspase inhibitor, indicating that an alternative caspase-independent pathway may also be involved. Our study suggests that gamma-tocopherol may be valuable in the prevention and therapy for certain types of cancer.