Fat cell progenitors get singled out.
Fat cell progenitors get singled out.
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脂肪细胞祖细胞被挑选出来。
DOI：
10.1126/science.aax2967
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Chau YY
中科院分区：
文献类型：
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作者：
Chau YY
脂肪组织对于安全储存多余的卡路里是必不可少的，因此在代谢健康中起着关键作用。通过储存脂滴，脂肪细胞（脂肪细胞）保护器官免受异位脂质积聚的破坏作用（1）。因此，了解如何促进健康的脂肪膨胀可能会揭示肥胖和相关疾病的治疗方法。这种扩张依赖于脂肪组织内祖细胞形成新的脂肪细胞（2）。脂肪祖细胞（APC）的不同群体已被确定，但它们的相互关系和生理和病理脂肪扩张的相关性仍然知之甚少（3）。在第353页的这个问题，梅里克特。(4)鉴定了三种新的受肥胖调节的APC，其中一种存在于组织再生和修复的潜在的新干细胞生态位中。
Fat tissue is essential for the safe storage of excess calories and thereby plays a key role in metabolic health. By storing lipid droplets, fat cells (adipocytes) protect organs from the damaging effects of ectopic lipid accumulation (1). Understanding how to promote healthy fat expansion may therefore reveal treatments for obesity and related diseases. Such expansion depends on the formation of new adipocytes from progenitor cells within fat tissue (2). Distinct populations of adipocyte progenitor cells (APCs) have been identified, but their interrelationships and relevance to physiological and pathological fat expansion have remained poorly understood (3). On page 353 of this issue, Merricket al.(4) identify three new classes of APCs that are regulated with obesity, one of which resides in a potential new stem cell niche for tissue regeneration and repair.