BRAIN-CELL AND TISSUE RECOVERY IN RATS MADE DEFICIENT IN N-3 FATTY-ACIDS BY ALTERATION OF DIETARY-FAT
BRAIN-CELL AND TISSUE RECOVERY IN RATS MADE DEFICIENT IN N-3 FATTY-ACIDS BY ALTERATION OF DIETARY-FAT
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DOI：
10.1093/jn/119.1.15
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发表时间：
1989-01-01
影响因子：
4.2
通讯作者：
YOUYOU, A
中科院分区：
文献类型：
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作者：
BOURRE, JM;DURAND, G;YOUYOU, A
给大鼠饲喂含有1.5%葵花籽油[940 mg亚油酸[18:2(n-6)]/100 g的纯化日粮；6毫克。-亚麻酸[18:3(n-3)]/100 g日粮]或1.9%大豆油[940 mg 18:2(n-6)/100 g日粮：130 mg 18:3(n-3)/100 g日粮]。在所有细胞和组织中，葵花籽油喂养的大鼠比大豆油喂养的大鼠22:6（n-3）更低，22:5（n-6）更高。22:4（n-6）和20:4（n-6）的水平基本上不受影响。以大豆油喂养大鼠的百分比表示，葵花籽油喂养大鼠的22:6（n-3）如下：神经元，49；星形胶质细胞,47岁;少突胶质细胞,10;肺,27岁;睾丸,32;视网膜,36个;肝脏，35，肾脏，45。60 d龄大鼠从葵花籽油改为大豆油，10周后，脑细胞脂肪酸组成未达到连续饲喂大豆油的对照组；22:6（n-3）分别为星形胶质细胞、少突胶质细胞和神经元对照水平的77%、65%和80%。相比之下，通过22:5（n-6）衰减测量的恢复在10周内完成。对于22:6(n-3)，肝脏和肾脏恢复到控制值大约需要2周，肺需要3周，视网膜需要6周，睾丸需要10周。22:5（n-6）下降迅速：肾、肝、肺在2周内达到控制值，视网膜在6周内达到控制值。由于脑细胞对22:6（n-3）含量的恢复非常缓慢，因此必须非常仔细地确定长链脂肪酸前体的最佳比例。
Rats were fed a purified diet containing either 1.5% sunflower oil [940 mg linoleic acid [18:2(n-6)]/100 g diet; 6 mg .alpha.-linolenic acid [18:3(n-3)]/100 g diet] or 1.9% soybean oil [940 mg 18:2(n-6)/100 g diet: 130 mg 18:3(n-3)/100 g diet]. In all cells and tissues examined 22:6(n-3) was lower and 22:5(n-6) was higher in rats fed sunflower oil than in rats fed soybean oil. Levels of 22:4(n-6) and 20:4(n-6) were largely unaffected. Expressed as a percentage of that in soybean oil-fed rats, 22:6(n-3) in sunflower oil-fed rats was as follows: neurons, 49; astrocytes, 47; oligodendrocytes, 10; lung, 27; testes, 32; retina, 36; liver, 35 and kidneys, 45. Ten wk after the change in diet of 60-d-old rats from one containing sunflower oil to one containing soybean oil, the fatty acid composition of the brain cell had not reached control values, e.g., that obtained in animals continuously fed soybean oil; 22:6(n-3) was 77, 65 and 80% of control levels for astrocytes, oligodendrocytes and neurons, respectively. In contrast, the recovery measured by the decay of 22:5(n-6) was complete within 10 wk. For 22:6(n-3), it look approximately 2 wk for liver and kidney to recover to the control value, 3 wk for lung, 6 wk for retina and 10 wk for testes. The decrease of 22:5(n-6) was rapid: the control values were reached within 2 wk for kidney, liver and lung with and within 6 wk for retina. Because the recovery of the content of 22:6(n-3) by brain cells was very slow, the optimal ratio of long-chain fatty acid precursors must be determined very carefully.