Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury-Induced Neuropathic Pain Models
Single Application of A2 NTX, a Botulinum Toxin A2 Subunit, Prevents Chronic Pain Over Long Periods in Both Diabetic and Spinal Cord Injury-Induced Neuropathic Pain Models
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DOI：
10.1254/jphs.12080sc
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发表时间：
2012-07-01
影响因子：
3.5
通讯作者：
Ueda, Hiroshi
中科院分区：
文献类型：
--
作者：
Ma, Lin;Nagai, Jun;Ueda, Hiroshi
A型肉毒毒素是一种独特的抑制疼痛传递的候选药物。在本研究中，我们试图观察A型肉毒毒素的活性亚基A2神经毒素(NTX)的有益作用。在糖尿病神经病理性疼痛模型中，足底注射A2 NTX显著抑制机械性痛觉过敏和对A纤维刺激的超敏反应。在脊髓损伤诱导的神经病理性疼痛模型中，脊髓应用A2 NTX也显示出对热痛敏和机械痛敏的有效抑制。A2 NTX对糖尿病和脊髓损伤所致的神经性疼痛似乎是一种持久的治疗方法。
Botulinum toxin type A is a unique candidate for inhibition of pain transmission. In the present study we attempted to see the beneficial actions of A2 neurotoxin (NTX), an active subunit of botulinum toxin type A. Intraplantar injection of A2 NTX significantly suppressed mechanical allodynia and hypersensitivities to A-fiber stimuli in the diabetic neuropathic pain model. Spinal application of A2 NTX also showed a potent suppression of thermal hyperalgesia and mechanical allodynia in the spinal cord injury-induced neuropathic pain model. A2 NTX seems to be a long-lasting treatment for diabetic and spinal cord injury induced-neuropathic pain.