Hepatitis C virus infection in infants whose mothers took street drugs intravenously.
Hepatitis C virus infection in infants whose mothers took street drugs intravenously.
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母亲静脉注射街头毒品的婴儿感染丙型肝炎病毒。
DOI：
10.1016/s0022-3476(05)83035-5
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Thaler,MM
中科院分区：
文献类型：
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作者：
Weintrub,PS;Veereman-Wauters,G;Cowan,MJ;Thaler,MM
为了评估妊娠或分娩期间母婴传播丙型肝炎病毒的风险，我们采用酶联免疫吸附试验（ELISA）和重组免疫印迹试验（RIBA）检测了43名母亲静脉注射违禁药物的婴儿血清中的丙型肝炎病毒抗体（抗hcv）。在43名婴儿中，有17名（40%）在出生后的头4个月内检测到被动传播的母体抗- hcv。其中10名最初血清阳性的婴儿被随访至15个月或更大；9名婴儿的hcv抗体被清除，1名持续存在。在24名最初血清阴性的婴儿中，3名（12.5%）分别在6个月、11个月和18个月时表现出持续的抗- hcv。其余两名婴儿在6个月和15个月大时进行了ELISA检测；两者都是短暂的血清阳性，但抗- hcv分别在12个月和24个月时消失。在17例母源抗体患儿中，ELISA反应大于2.5光密度单位的患儿中9例RIBA有反应；ELISA反应较弱的患儿中8例RIBA无反应。当用RIBA检测4例经ELISA显示持续反应性的婴儿的血清样本时，1例对RIBA显示的两种抗原（C-100和5-1-1）都有反应，1例只对5-1-1抗原有反应，2例无反应。这4名婴儿中有3名血清转氨酶值升高；这四人都感染了人类免疫缺陷病毒。结果提示，垂直传播的丙型肝炎病毒可能是婴儿肝炎的一个病因，特别是合并感染人类免疫缺陷病毒的婴儿。有丙型肝炎病毒感染风险的新生儿应在12个月以上进行监测。婴儿期抗丙型肝炎抗体检测的解释需要进一步调查。
To assess the risk of transmission of hepatitis C virus from mother to infant during pregnancy or at delivery, we measured the antibody to hepatitis C virus (anti-HCV) by an enzyme-linked immunosorbent assay (ELISA) and a recombinant immunoblot assay (RIBA) in serum from 43 infants whose mothers took illicit drugs intravenously. Passively transmitted maternal anti-HCV was detected in 17 (40%) of the 43 infants tested with the ELISA during the first 4 postnatal months. Ten of these initially seropositive infants were followed to 15 months of age or beyond; anti-HCV cleared from nine infants and persisted in one. Among 24 initially seronegative infants, three (12.5%) showed persistent anti-HCV at 6, 11, and 18 months of age, respectively. The remaining two infants were initially tested with ELISA at 6 and 15 months of age; both were transiently seropositive, but anti-HCV disappeared by 12 and 24 months of age, respectively. Among the 17 infants with maternal antibody, nine with ELISA reactions greater than 2.5 optical density units were reactive by RIBA: the eight with weaker reactivity by ELISA were nonreactive by RIBA. When serum samples from the four infants who showed persistent reactivity by ELISA were tested with RIBA, one, reacted to both antigens displayed by RIBA (C-100 and 5-1-1), one reacted to the 5-1-1 antigen only, and two were nonreactive. Serum transaminase values were elevated in three of these four infants; all four were also infected with human immunodeficiency virus. The results indicate that vertically transmitted hepatitis C virus may be a cause of hepatitis in infants, especially those coinfected with human immunodeficiency virus. Neonates at risk of hepatitis C virus infection should be monitored beyond 12 months of age. The interpretation of tests for anti-HCV antibody during infancy requires further investigation.