Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema
Enhanced immediate inflammatory response to Streptococcus pneumoniae in the lungs of mice with pulmonary emphysema
复制标题
DOI：
10.1111/j.1440-1843.2007.01229.x
复制
发表时间：
2008-05
期刊：
影响因子：
6.9
通讯作者：
Yoshikane Tokairin;Y. Shibata;M. Sata;S. Abe;N. Takabatake;A. Igarashi;T. Ishikawa;S. Inoue;I. Kubota
中科院分区：
文献类型：
--
作者：
Yoshikane Tokairin;Y. Shibata;M. Sata;S. Abe;N. Takabatake;A. Igarashi;T. Ishikawa;S. Inoue;I. Kubota
背景和目的：肺气肿与频繁的呼吸道感染有关，但对细菌感染易感性的原因知之甚少。我们先前证明了在实验性肺气肿小鼠模型中，在细菌接种后24小时或更长时间内对肺炎链球菌的炎症反应受损。Toll样受体（TLR）已被认为是炎症反应的调节因子。我们检测了实验性肺气肿小鼠肺泡巨噬细胞TLR的表达，并评估了肺气肿肺对链球菌感染的即时炎症反应。
Background and objective: Pulmonary emphysema is associated with frequent respiratory infections but little is known about the reasons for this susceptibility to bacterial infection. We previously demonstrated an impaired inflammatory response to Streptococcus pneumoniae in an experimental emphysema mouse model at 24 h, or longer following bacterial inoculation. Toll‐like receptors (TLR) have been recognized as regulators in the inflammatory response. We examined the expression of TLR on alveolar macrophages in experimental emphysema mice and evaluated the immediate inflammatory response of the emphysematous lung to streptococcal infection.