Histone demethylases and cancer.
Histone demethylases and cancer.
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DOI：
10.1016/s0065-230x(09)02004-1
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发表时间：
2009
影响因子：
--
通讯作者：
Tsichlis, Philip N.
中科院分区：
文献类型：
--
作者：
Kampranis, Sotirios C.;Tsichlis, Philip N.
表观遗传修饰是可遗传的染色质改变，有助于基因组的时间和空间解释。表观遗传信息通过多种化学修饰传递，包括DNA甲基化、组蛋白的可逆修饰和ATP依赖性核小体重塑。表观遗传机制的失调有助于包括癌症在内的几种病理学的发展。染色质修饰是多种多样的，相互依赖的，它们在各种生物过程中动态调节。染色质修饰的组合产生了一个复杂的密码，该密码叠加在嵌入DNA序列的遗传密码上，以调节细胞功能。本文综述了表观遗传修饰在癌症中的作用，主要集中在组蛋白甲基化标记和催化其去除的酶。
Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications, including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the role of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal.