RECEPTOR FOR ALBUMIN ON THE LIVER-CELL SURFACE MAY MEDIATE UPTAKE OF FATTY-ACIDS AND OTHER ALBUMIN-BOUND SUBSTANCES
RECEPTOR FOR ALBUMIN ON THE LIVER-CELL SURFACE MAY MEDIATE UPTAKE OF FATTY-ACIDS AND OTHER ALBUMIN-BOUND SUBSTANCES
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DOI：
10.1126/science.6258226
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
OCKNER, R
中科院分区：
文献类型：
--
作者：
WEISIGER, R;GOLLAN, J;OCKNER, R
在大鼠肝脏单次灌注中对\(^{14}C\)-油酸摄取的动力学分析，以及\(^{125}I\)-白蛋白与悬浮肝细胞的可饱和特异性结合，表明肝细胞表面存在白蛋白受体。该假定的受体似乎介导细胞对白蛋白结合脂肪酸的摄取，并可能解释肝脏对许多其他与白蛋白紧密结合的物质的高效摄取。
Kinetic analysis of the uptake of 14C-oleate in a single-pass perfusion of rat liver and saturable and specific binding of 125I-albumin to hepatocytes in suspension suggest the existence of a receptor for albumin on the liver cell surface. The putative receptor appears to mediate uptake of albumin-bound fatty acids by the cell and may account for the efficient hepatic extraction of many other substances tightly bound to albumin.