Chemokines: Inflammatory mediators of atherosclerosis
Chemokines: Inflammatory mediators of atherosclerosis
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DOI：
10.1080/13813450601093583
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发表时间：
2006-10-01
影响因子：
3
通讯作者：
Weber, Christian
中科院分区：
文献类型：
--
作者：
Liehn, Elisa A.;Zernecke, Alma;Weber, Christian
动脉粥样硬化作为心肌梗塞、中风和外周动脉疾病的根本机制，仍然是发达国家发病和死亡的主要原因。血管生物学的最新发展表明，动脉粥样硬化的最佳特征是血管壁的慢性炎症性疾病，可促进病变的发生和进展。趋化因子通过协调循环血细胞与动脉壁的粘附相互作用及其随后的外渗来调节和控制这些过程。不同的趋化因子表现出高度的专业化和协作性，在单核细胞和 T 细胞募集动脉粥样硬化过程中介导不同的步骤。趋化因子表达和功能的这种多样性可能有助于确定预防和治疗动脉粥样硬化的选择性治疗靶点。
Atherosclerosis as the underlying mechanisms of myocardial infarction, stroke and peripheral artery disease remains the major cause of morbidity and mortality in developed countries. Recent developments in vascular biology have indicated that atherosclerosis can be best characterized as a chronic inflammatory disease of the vessel wall that promotes lesion development and progression. Chemokines regulate and control these processes by orchestrating adhesive interactions of circulating blood cells with the arterial wall and their subsequent extravasation. Exhibiting a high degree of specialization and cooperation, different chemokines mediate distinct steps during the atherogenic recruitment of monocytes and T cells. This diversity of chemokine expression and function might lead to the identification of selective therapeutic targets for the prevention and treatment of atherosclerotis.